744253-34-7

Upstream product

• 75-16-1 methylmagnesium bromide 
• 190083-97-7 [6-(cyclopropylmethyl-propyl-amino)-2,5-dimethyl-pyrimidin-4-yl]-(2,4,6-trimethoxy-phenyl)-methanone 
• 744253-41-6 2,5-dimethyl-4-(N-propyl-N-cyclopropylmethyl-amino)-pyrimidine-6-carboxylic acid, ethyl ester 
• 74536-25-7 2,5-dimethylpyrimidine 
• 76498-32-3 Ethyl 4-Chloro-2,5-dimethylpyrimidine-6-carboxylate 
• 2418-31-7 (E)-2-methyl-but-2-enedioic acid diethyl ester 
• 759-65-9 diethyl oxalpropionate 

Downstream Products

• 190084-04-9 cyclopropylmethyl-{2,5-dimethyl-6-[1-(2,4,6-trimethoxy-phenyl)-vinyl]-pyrimidin-4-yl}-propyl-amine 

Relevant academic research and scientific papers

Synthesis of benzoylpyrimidines as antagonists of the corticotropin- releasing factor-1 receptor

A series of benzoylpyrimidines derived from the anilinepyrimidine CRF 1 antagonists were synthesized. Several synthetic routes were developed to explore the SAR of this series of compounds. Compounds such as 8d (Ki=15nM) exhibited high binding affinities at the human CRF 1 receptor.