745041-72-9Relevant articles and documents
Synthesis and biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile
Toba, Tetsuya,Murata, Kenji,Futamura, Junko,Nakanishi, Kyoko,Takahashi, Bitoku,Takemoto, Naohiro,Tomino, Minako,Nakatsuka, Takashi,Imajo, Seiichi,Goto, Megumi,Yamamura, Takashi,Miyake, Sachiko,Annoura, Hirokazu
scheme or table, p. 2850 - 2859 (2012/07/01)
A series of truncated analogs of α-galactosylceramide with altered ceramide moiety was prepared, and evaluated for Th2-biased response in the context of IL-4/IFN-γ ratio. Phytosphingosine-modified analogs including cyclic, aromatic and ethereal compounds
Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokine induction and the discovery of non-linear phytosphingosine analogs
Toba, Tetsuya,Murata, Kenji,Nakanishi, Kyoko,Takahashi, Bitoku,Takemoto, Naohiro,Akabane, Minako,Nakatsuka, Takashi,Imajo, Seiichi,Yamamura, Takashi,Miyake, Sachiko,Annoura, Hirokazu
, p. 2781 - 2784 (2008/02/05)
Analogs of immunomodulatory glycolipid OCH (2) were prepared and minimum structure requirement to exhibit equivalent profiles was disclosed. Analogs bearing non-linear hydrocarbon chain in the phytosphingosine moiety (18, 19) were shown for the first time
Total synthesis of an immunosuppressive glycolipid, (2S,3S,4R)-1-O- (α-D-galactosyl)-2-tetracosanoylamino-1,3,4-nonanetriol
Murata, Kenji,Toba, Tetsuya,Nakanishi, Kyoko,Takahashi, Bitoku,Yamamura, Takashi,Miyake, Sachiko,Annoura, Hirokazu
, p. 2398 - 2401 (2007/10/03)
(Chemical Equation Presented) A practical and efficient total synthesis of (2S,3S,4R)-1-O-(α-D-galactosyl)-2-tetracosanoylamino-1,3,4-nonanetriol, OCH 1b, a potential therapeutic candidate for Th1-mediated autoimmune diseases, is described. The synthesis