74632-96-5Relevant academic research and scientific papers
Preparation of α-functionalized alkenylmagnesium reagents via a halide-magnesium exchange
Thibonnet, Jér?me,Anh Vu, Viet,Bérillon, Laurent,Knochel, Paul
, p. 4787 - 4799 (2007/10/03)
A general preparation of alkenylmagnesium derivatives bearing an electron-withdrawing function in the α-position (Y=CN, CO2R, CONR2, SO2Ph) has been made possible by using a low temperature (-40 to -30°C) bromine-magnesium exchange with i-PrMgBr in THF. This reaction has also been used to prepare 5-magnesiated-1,3-dioxin-4-one derivatives bearing an alkoxy substituent in β-position to the carbon-magnesium bond.
Preparation of functionalized alkenylmagnesium bromides via a bromine- magnesium exchange
Thibonnet, Jér?me,Knochel, Paul
, p. 3319 - 3322 (2007/10/03)
α-Bromonitriles, such as 1, 2 or the α-bromosulfone 3, undergo a smooth bromine-magnesium exchange with isopropylmagnesium bromide furnishing new functionalized organomagnesium species which react smoothly with various electrophiles like Me3SiCl, Bu3SnCl, allyl bromides, aldehydes, ketones or acid chlorides providing the expected products of type 7, 8 or 9. (C) 2000 Elsevier Science Ltd.
HETEROCONJUGATE ADDITION OF LITHIUM ALKYLS TO SUBSTITUTED HETERO-OLEFINS CONJUGATED WITH SULFUR AND SILICON ATOMS
Isobe, Minoru,Kitamura, Masato,Goto, Toshio
, p. 331 - 334 (2007/10/02)
Lithium alkyls and a lithiated sulfone carbanion readily added to the substituted hetero-olefins conjugated with silicon and sulfone-sulfur atoms among other combination of the third (or fourth) row hetero atoms, e.g.Si, Se and S.
