74695-46-8 Usage
Uses
Used in Pharmaceutical Industry:
7-Chloro-5-methoxythieno[3,2-b]pyridine is used as a building block for the synthesis of various pharmaceuticals due to its demonstrated potential biological activities. It plays a crucial role in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 7-Chloro-5-methoxythieno[3,2-b]pyridine is utilized as a key intermediate in the production of agrochemicals. Its unique structure and properties make it suitable for the creation of compounds that can be used in agricultural applications to protect crops and enhance yield.
Used in Materials Science:
7-Chloro-5-methoxythieno[3,2-b]pyridine is also used in materials science as a component in the synthesis of new materials. Its incorporation can lead to the development of materials with specific properties required for various applications, such as in electronics or advanced materials research.
Used in Chemical Research and Drug Discovery:
7-Chloro-5-methoxythieno[3,2-b]pyridine serves as a valuable tool in chemical research, providing insights into the structure-activity relationships of related compounds. It is instrumental in drug discovery processes, aiding researchers in identifying and optimizing potential drug candidates with improved efficacy and safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 74695-46-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,6,9 and 5 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 74695-46:
(7*7)+(6*4)+(5*6)+(4*9)+(3*5)+(2*4)+(1*6)=168
168 % 10 = 8
So 74695-46-8 is a valid CAS Registry Number.
74695-46-8Relevant academic research and scientific papers
Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: Potent antibacterially active non-quinolone analogues
Jarvest, Richard L.,Armstrong, Sula A.,Berge, John M.,Brown, Pamela,Elder, John S.,Brown, Murray J.,Copley, Royston C.B.,Forrest, Andrew K.,Hamprecht, Dieter W.,O'Hanlon, Peter J.,Mitchell, Darren J.,Rittenhouse, Stephen,Witty, David R.
, p. 3937 - 3941 (2007/10/03)
Potent inhibitors of bacterial methionyl tRNA synthetase (MRS) have previously been reported. Through SAR of the quinolone moiety, the right hand side pharmacophore for MRS inhibition has now been defined as an NH-C-NH functionality in the context of a bicyclic heteroaromatic system. Potent antibacterial fused-pyrimidone and fused-imidazole analogues have been obtained and enantioselective activity demonstrated. Compound 46 demonstrated very good antibacterial activity against panels of antibiotic-resistant staphylococci and enterococci.
Thienopyridines. Part 3. The Preparation of Some 6-Substituted 7-Hydroxythienopyridin-5(4H)-ones and Some Reactions of 7-Hydroxythienopyridin-5(4H)-one.
Barker, John M.,Huddleston, Patrick R.,Chadwick, Nigel,Keenan, Guy J.
, p. 113 - 126 (2007/10/02)
Reaction of 3-amino-2-alkoxycarbonylthiophens with compounds such as diethyl malonate or ethyl cyanoacetate produced amides, which were cyclised to 6-substituted-7-hydroxythienopyridin-5(4H)-ones by treatment with sodium hydride in dimethyl-formamide.Hydrolysis of the 6-ethoxycarbonyl derivative yielded 7-hydroxythienopyridin-5(4H)-one; some aspects of the chemistry of this substance, and of chloro-compounds derived from it, have been studied.
