7472-45-9

Upstream product

• 7505-87-5 chloro-diphenyl-acetic acid methylamide 
• 623-59-6 N-acetyl-N'-methylurea 
• 141-52-6 sodium ethanolate 
• 52182-15-7 ethyl benzilate 
• 83490-71-5 N?methyl?2?oxo?2?phenylacetamide 
• 100-58-3 phenylmagnesium bromide 
• 141694-25-9 N-methoxy-N-methyl-α-oxo-benzeneacetamide 
• 41601-09-6 5,5-diphenyl-1,5-dihydro-[1,2,3]triazol-4-one 
• 2902-98-9 2-chloro-2,2-diphenylacetyl chloride 
• 76-89-1 methyl benzilate 
• 74-89-5 methylamine 

Relevant academic research and scientific papers

α-Keto Amides and 1,2-Diketones from N,N'-Dimethoxy-N,N'-dimethylethanediamide. A Synthetic and Mechanistic Investigation

N,N'-Dimethoxy-N,N'-dimethylethanediamide (1), a 1,2-dicarbonyl synthon prepared from oxalyl chloride, undergoes nucleophilic displacements with Grignard reagents to provide α-keto amides 2-12 in 28-90percent yields.The synthon also undergoes double nucleophilic displacements with organolithium reagents to furnish symmetrical 1,2-diketones 15-23 in 15-84percent yields.A mechanism accounting for all the products from the reaction of 1 with nucleophiles has been proposed.Several control experiments were carried out to support the proposed mechanism.