N-Methylbenzilamide

Base Information

• Chemical Name: N-Methylbenzilamide
• CAS No.: 7472-45-9
• Molecular Formula: C15H15NO2
• Molecular Weight: 241.29
• NSC Number: 401954
• UNII: C3FS9XNY8L
• DSSTox Substance ID: DTXSID30225704
• Wikidata: Q83104804
• Mol file: 7472-45-9.mol

Synonyms:N-Methylbenzilamide;Benzilamide, N-methyl-;7472-45-9;C3FS9XNY8L;NSC 401954;alpha-Hydroxy-N-methyl-alpha-phenylbenzeneacetamide;BRN 2121467;Benzeneacetamide, alpha-hydroxy-N-methyl-alpha-phenyl-;NSC-401954;2-hydroxy-n-methyl-2,2-diphenylacetamide;NSC401954;UNII-C3FS9XNY8L;SCHEMBL4620848;DTXSID30225704;LS-32446;Benzeneacetamide, alpha-hydroxy-N-methyl-alpha-phenyl- (9CI)

Chemical Property of N-Methylbenzilamide

Chemical Property:

• Vapor Pressure: 3.7E-10mmHg at 25°C
• Boiling Point: 483.4°Cat760mmHg
• Flash Point: 246.2°C
• Density: 1.17g/cm³
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 241.110278721
• Heavy Atom Count: 18
• Complexity: 260

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CNC(=O)C(C1=CC=CC=C1)(C2=CC=CC=C2)O

Technology Process of N-Methylbenzilamide

There total 9 articles about N-Methylbenzilamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N?methyl?2?oxo?2?phenylacetamide (83490-71-5) + phenylmagnesium bromide (100-58-3) → 2,2-Diphenyl-2-hydroxy-N-methylacetamide (7472-45-9)

Guidance literature:

In diethyl ether; for 18h; Heating;

DOI:10.1021/jo00121a021

Reference yield: 26.0%

N-methoxy-N-methyl-α-oxo-benzeneacetamide (141694-25-9) + phenylmagnesium bromide (100-58-3) → N-methylbenzamide (88070-48-8) + triphenylmethyl alcohol (76-84-6) + 2,2-Diphenyl-2-hydroxy-N-methylacetamide (7472-45-9) + 2,2-Diphenyl-2-hydroxy-N-methoxy-N-methylacetamide

Guidance literature:

In tetrahydrofuran; for 18h; Heating;

DOI:10.1021/jo00121a021

Reference yield:

N-acetyl-N'-methylurea (623-59-6) + sodium ethanolate (141-52-6) + ethyl benzilate (52182-15-7) → 2,2-Diphenyl-2-hydroxy-N-methylacetamide (7472-45-9) + Benzilic acid (76-93-7)

Guidance literature:

upstream raw materials:

chloro-diphenyl-acetic acid methylamide

methyl benzilate

methylamine

N-acetyl-N'-methylurea