74944-11-9

Basic information

• Product Name: 2-phenylimidazo[1,2-a]quinoline
• Synonyms: 2-phenylimidazo[1,2-a]quinoline
• CAS NO: 74944-11-9
• Molecular Formula: C₁₇H₁₂N₂
• Molecular Weight: 244.29058
• Mol File: 74944-11-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-phenylimidazo[1,2-a]quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenylimidazo[1,2-a]quinoline(74944-11-9)
• EPA Substance Registry System: 2-phenylimidazo[1,2-a]quinoline(74944-11-9)

Safety Data

• Hazardous Substances Data: 74944-11-9(Hazardous Substances Data)

Upstream product

• 33014-32-3 1-phenacylquinolinium bromide 
• 95-53-4 o-toluidine 
• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 
• 50502-17-5 N-(quinolin-2-yl)acetamide 
• 213334-93-1 o-((trimethylsilyl)ethynyl)phenyl isocyanide 
• 112671-40-6 2-(trimethylsilylethynyl)formanilide 
• 580-22-3 2-aminoquinoline 
• 70-11-1 α-bromoacetophenone 
• 98-86-2 acetophenone 
• 100-42-5 styrene 
• 91-22-5 quinoline 
• 4636-16-2 iodoacetophenone 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 98-88-4 benzoyl chloride 

Downstream Products

• 70845-60-2 2-phenyl-1,2-dihydroimidazo[1,2-a]quinoline-1-carbonitrile 
• 33357-46-9 N-(quinolin-2-yl)benzamide 
• 58417-55-3 3-phenyl-1H-[1,3,5]triazino[1,2-a]quinolin-1-one 

Relevant articles and documents

Solvent-Dependent Cyclization of 2-Alkynylanilines and ClCF2COONa for the Divergent Assembly of N-(Quinolin-2-yl)amides and Quinolin-2(1 H)-ones

Herein, we present an expedient Cu-catalyzed [5 + 1] cyclization of 2-alkynylanilines and ClCF2COONa to divergent construction of N-(quinolin-2-yl)amides and quinolin-2(1H)-ones by regulating the reaction solvents. Notably, nitrile acts as a solvent and performs the Ritter reactions. ClCF2COONa is used as a C1 synthon in this transformation, which also represents the first example for utilization of ClCF2COONa as an efficient desiliconization reagent. The current protocol involves in situ generation of isocyanide, copper-activated alkyne, Ritter reaction and protonation.

Iodine-Mediated Sulfenylation of Imidazo[1,2- a ]pyridines with Ethyl Arylsulfinates

A simple iodine-mediated approach is reported for the synthesis of sulfenylated imidazo[1,2- a ]pyridines through the reaction of imidazo[1,2- a ]pyridines with ethyl arylsulfinates under mild conditions. The reaction scope was investigated, and a plausible mechanism is proposed to elucidate the reaction process and activation mode. The results indicate that ethyl sulfinates are efficient sulfur sources for the construction of C-S bonds.

Electrochemically initiated intermolecular C-N formation/cyclization of ketones with 2-aminopyridines: An efficient method for the synthesis of imidazo[1,2-: A] pyridines

Electrochemical intermolecular C-N formation/cyclization of ketones with 2-aminopyridines using catalytic hydriodic acid as the redox mediator was developed, providing imidazo[1,2-a]pyridines under more environmentally benign conditions. The reaction proceeds in a simple undivided cell, using low toxic ethanol as the solvent, without external oxidants, and exhibits high atom economy. A variety of ketones including acetophenones, unsatruated and alkyl ketones are amenable to this reaction, affording the corresponding products in moderate to excellent yields. A three-component tandem reaction realizing C-N, C-S/C-Se bond formation can also be achieved under standard conditions.