7497-45-2

Usage

Dinitrile derivative

acetophenone 2-(4-methoxyphenyl)-3-phenylbutanedinitrile is derived from acetophenone by replacing two hydrogen atoms with cyano groups (CN), making it a dinitrile.

Organic compound class

benzodinitriles 2-(4-methoxyphenyl)-3-phenylbutanedinitrile belongs to the class of organic compounds known as benzodinitriles, which are characterized by their aromatic ring structure and two cyano groups.

Precursor in synthesis

pharmaceuticals and organic compounds 2-(4-methoxyphenyl)-3-phenylbutanedinitrile is often used as a starting material or precursor in the synthesis of various pharmaceuticals and other organic compounds, making it a versatile chemical building block.

Upstream product

• 5432-07-5 4-methoxy-α-phenylcinnamonitrile 
• 151-50-8 potassium cyanide 
• 64-17-5 ethanol 
• 100-52-7 benzaldehyde 
• 773837-37-9 sodium cyanide 
• 5840-59-5 3-phenyl-2-(4-methoxyphenyl)acrylonitrile 
• 104-47-2 p-methoxybenzylnitrile 
• 140-29-4 phenylacetonitrile 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 41915-62-2 (+/-)-erythro-3-phenyl-2-(4-methoxy-phenyl)-succinic acid 
• 41915-62-2 2-(4-methoxy-phenyl)-3-phenyl-succinic acid 

Relevant academic research and scientific papers

Synthesis of non-symmetrical 3,4-diaryl-substituted pyrroles: Implementation for the preparation of lamellarin R

A straightforward method for synthesising symmetrical and non-symmetrical 3,4-diaryl-substituted pyrroles is proposed, consisting of (i) the condensation reaction between phenylacetonitriles and aldehydes to give acrylonitriles, (ii) the conjugate additio

A Paal-Knorr approach to 3,4-diaryl-substituted pyrroles: Facile synthesis of lamellarins O and Q

A very simple, yet efficient synthetic methodology, to obtain 3,4-diaryl-substituted pyrroles is described. The approach is based on the Knoevenagel condensation between arylacetonitriles and substituted aromatic aldehydes, followed by conjugate addition of cyanide to afford succinonitriles in excellent yields. The products thus obtained were subjected to DIBAL-H reduction, followed by cyclization under acidic conditions to produce the corresponding pyrroles in good overall yields. The utility of this protocol is exemplified by the synthesis of the marine alkaloids lamellarins O and Q.