7497-59-8

Upstream product

• 728-22-3 3-(4-methoxybenzene)-5-chloro-2,1-benzoisoxazole 
• 7033-50-3 6-chloro-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 
• 20028-53-9 2-amino-5-chlorobenzaldehyde 
• 5720-07-0 4-methoxyphenylboronic acid 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 34999-44-5 5-Chlor-2--4'-methoxy-benzophenon 
• 67-56-1 methanol 
• 869365-90-2 N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]-4-fluoro-benzamide 
• 635-21-2 5-chloroanthranilic acid 

Downstream Products

• 7039-51-2 (2-amino-5-chloro-phenyl)-(4-methoxy-phenyl)-methanol 
• 784-41-8 2-amino-5-chloro-4'-hydroxy-benzophenone 
• 35001-96-8 6-chloro-4-(4-methoxy-phenyl)-2-methylsulfanyl-4H-benzo[d][1,3]thiazine 
• 35001-84-4 6-chloro-4-(4-methoxy-phenyl)-1,4-dihydro-benzo[d][1,3]thiazine-2-thione 
• 1584736-21-9 C₁₇H₁₆ClNO₄ 
• 728-22-3 3-(4-methoxybenzene)-5-chloro-2,1-benzoisoxazole 

Relevant academic research and scientific papers

Synthesis of 3-Substituted 2,1-Benzisoxazoles by the Oxidative Cyclization of 2-Aminoacylbenzenes with Oxone

An efficient approach to the synthesis of 2,1-benzisoxazoles through direct construction of the N-O bond by the chemoselective oxidation of 2-aminoacylbenzenes with Oxone is described. This alternative methodology is characterized by its simple and transition-metal-free conditions and good functional group compatibility utilizing Oxone as a green oxidant instead of hypervalent iodine compounds. Moreover, this new procedure simplifies the number of steps compared to the previously reported procedure by circumventing the use of 2-azido-substituted aryl ketones.

Concise Synthesis of 4-Arylquinolines via Intramolecular Cyclization of Allylamines and Ketones

The intramolecular cyclization of allylamines and ketones was achieved in the presence of potassium tert-butoxide and N,N-dimethylformamide. A series of 4-arylquinolines was prepared in good yields. The reaction could be accomplished at room temperature using only a substoichiometric amount of potassium tert-butoxide. On the other hand, the reaction of the structurally analogous allyl ethers afforded diverse products. The reaction may proceed via the rearrangement of α-aminoallyl radicals and the generation of nucleophilic enamine intermediates. This finding represents a new strategy for the synthesis of quinoline derivatives from readily available 2-(allylamino)phenyl ketones.

Compounds and methods for inhibiting mitotic progression

This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treat

Preparation of 2-arninpbenzophenones and polysubstituted quinolines through Sml2 promoted reductive cleavage of 3-aryl-2,1-benzisoxazoles

Promoted by SmI2, 3-aryl-2,1-benzisoxazoles underwent reductive cleavage of the N - O bond leading to 2-aminobenzophenones in high yields upon protonation. Otherwise, if ketones with active methylene group were added to the reaction mixture prior to protonation, the desired poly substituted quinolines could be obtained under mild conditions in a one-pot manner.

SmI2-mediated facile one-pot preparation of 2,4-diarylquinolines from 3-aryl-2,1-benzisoxazoles

On treatment with SmI2, 3-aryl-2,1-benzisoxazoles undergo reductive cleavage of the N-O bond leading to 2-aminobenzophenones in high yields upon protonation. If aryl methyl ketones are added to the reaction mixture prior to protonation, the desired 2,4-diarylquinolines can be obtained in moderate yields under mild conditions.