7497-63-4

Basic information

• Product Name: ethyl 4-(diethylamino)-4-oxobutanoate
• CAS NO: 7497-63-4
• Molecular Formula: C₁₀H₁₉NO₃
• Molecular Weight: 201.2628
• Mol File: 7497-63-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 296.1°C at 760 mmHg
• Flash Point: 132.8°C
• Density: 0.999g/cm³
• Vapor Pressure: 0.00147mmHg at 25°C
• Refractive Index: 1.447
• CAS DataBase Reference: ethyl 4-(diethylamino)-4-oxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(diethylamino)-4-oxobutanoate(7497-63-4)
• EPA Substance Registry System: ethyl 4-(diethylamino)-4-oxobutanoate(7497-63-4)

Safety Data

• Hazardous Substances Data: 7497-63-4(Hazardous Substances Data)

Upstream product

• 108-30-5 succinic acid anhydride 
• 368-39-8 triethyloxonium fluoroborate 
• 109-89-7 diethylamine 
• 64-17-5 ethanol 
• 110793-11-8 trans-3-diethylcarbamoylpropenoic acid ethyl ester 
• 765230-15-7 4‐(diethylamino)‐4‐oxobut‐2‐enoic acid 
• 14794-31-1 ethyl 3-(chloroformyl)propionate 

Downstream Products

• 2683-56-9 4-(N,N-diethylamino)-1-butanol 
• 2955-65-9 octane-3,6-dione 
• 82272-17-1 4-oxo-hexanoic acid diethylamide 

Relevant articles and documents

A Library of Thermoresponsive, Coacervate-Forming Biodegradable Polyesters

We report on a new class of thermoresponsive biodegradable polyesters (TR-PE) inspired by polyacrylamides and elastin-like proteins (ELPs). The polyesters display reversible phase transition with tunable cloud point temperatures (Tcp) in aqueous solution as evidenced by UV-vis spectroscopy, 1H NMR, and DLS measurements. These polyesters form coacervate droplets above their lower critical solution temperature (LCST). The Tcp of the polyesters is influenced by the solutes such as urea, SDS, and NaCl. The Tcp of the copolymers shows a linear correlation with the composition of the polyesters indicating the ability to tune the phase change temperature. We also show that such thermoresponsive coacervates are capable of encapsulating small molecules such as Nile Red. Furthermore, the polyesters are hydrolytically degradable.

REDUCTION METHOD USING WATER AS PROTON SOURCE BY MEANS OF N-HETEROCYCLIC CARBENE

PROBLEM TO BE SOLVED: To provide a reduction method using water as a proton source by means of N-heterocyclic carbene, in which the N-heterocyclic carbene is used actively as a reaction accelerator to realize a hydrogenation reaction by using water as the proton source. SOLUTION: A solution, which is obtained by mixing: a reaction substrate shown at an upper stage of the following formulae; a precursor of the triazole-based N-heterocyclic carbene (NHC) shown at a lower stage; water; and 1,2-dimethoxyethane being a solvent, is reacted at 100°C or higher temperature for 2 hours or more while making the solution to pass through a microwave reaction unit and the reacted solution is subjected to reduced-pressure distillation to obtain a hydrogenated product. The formulae: (EWG1-EWG4 are each an ester group, a cyano group, a ketone group, an amido group or an imido group;R1-R5 are each a 1-20C aliphatic group, a 3-12C alicyclic group or 6-30C aromatic group) SELECTED DRAWING: None COPYRIGHT: (C)2016,JPO&INPIT

A ONE-POT CONVERSION OF CYCLIC ANHYDRIDES TO ETHYL ω-DIALKYLAMINOALKANOATES

Ethyl ω-dialkylaminoalkanoates are conveniently obtained in good yield by a one-pot procedure from cyclic anhydrides by successive treatment with a secondary amine, triethyloxonium fluoroborate, and sodium borohydride.