7498-53-5

Usage

InChI:InChI=1/C11H12O4/c1-6-4-8(11(14)15-3)5-7(2)9(6)10(12)13/h4-5H,1-3H3,(H,12,13)

Upstream product

• 341006-48-2 methyl 3,5-dimethyl-4-{[(trifluoromethyl)sulfonyl]oxy}benzoate 
• 6737-42-4 1,3-bis-(diphenylphosphino)propane 
• 3375-31-3 palladium diacetate 
• 80238-12-6 2,6-dimethyl-terephthalic acid 
• 1667-01-2 2,4,6-Trimethylacetophenone 
• 480-63-7 mesitylenecarboxylic acid 
• 67-56-1 methanol 

Downstream Products

• 632-46-2 2,6-dimethylbenzoic acid 
• 16752-16-2 4-amino-2,6-dimethyl benzoic acid 
• 118738-95-7 1-acetyl-2,6-dimethylbenzene-4-carboxylic acid 
• 18958-19-5 2,6-dimethyl-terephthalic acid-1-methyl ester 
• 52850-45-0 2,6-dimethyl-terephthalic acid-1-chloride-4-methyl ester 
• 7499-18-5 2,6-dimethyl-terephthalamic acid 

Relevant academic research and scientific papers

Dehydroamino acids

Compounds of formula 1 and 1-1, wherein R1 is hydrogen, hydroxy, amino or halogen, R2 is hydrogen, hydroxy, or halogen and R3 is hydrogen (Formula 1) or R1 is hydrogen and R2 and R3 taken together with the ethenylene group connecting them form phenyl, pyrrole, pyrroline, oxopyrroline, pyrazole, triazole, or imidazole (Formula 1-1), A is R4 R5 are hydrogen, methyl, ethyl or halogen except that R4 r5 cannot both be hydrogen; and 1) B is hydrogen, or lower alkyl; or 2) B is where R6 R7 R8 and R9 are independently hydrogen, hydroxy, aminosulfonyl, halogen, lower alkoxy, cyano, amino, lower alkyl, lower alkyl amino, or nitro; or 3) B is where R10 is hydrogen, hydroxy, halogen, or lower alkyl and C is a five- or six- membered ring with 0 to 3 heteroatoms which heteroatoms are selected from nitrogen, oxygen, and sulfur, which ring may be unsubstituted or mono- or di- substituted with lower alkyl, cycloalkyl, amino, or substituted amino; 4) B is where X and Y are independently methylene or nitrogen; or 5) B is where at leat one of T, U, V, or W is nitrogen, and any of T, U, V or W which is carbon may be substituted with lower alkyl, lower alkyl amino, lower alkoxy, hydroxy, aminosulfonyl, halogen, cyano, amino, or nitro; or 6) B is where Y is carbon or nitrogen; or 7) B is a five-membered aromatic ring with 1 to 3 heteratoms selected from nitrogen, oxygen, and sulfur which ring may be unsubstituted or mono- or di-substituted with lower alkyl, cycloalky, trifluoroloweralkyl, amino, halogen, substituted amino, or which ring may be fused with a 5 or 6 membered aromatic ring containing 0 to 3 heteroatoms which heteroatoms are selected from nitrogen, oxygen, and sulfur; and pharmaceutically acceptable salts thereof, and related prodrugs, pharmaceutical compositions and methods of treatment, which compounds are useful for treating psoriasis.

ARYLOXY AND ARYLACYLOXY METHYL KETONES AS THIOL PROTEASE INHIBITORS

Thiol protease inhibitors are disclosed having the formula: STR1 or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein:n is 0 or 1;m is 0, 1 or 2;X is H or an N-protecting group; each Y is independently an optionally protected α-amino acid residue;R is an optionally protected α-amino acid side chain that is H or CH 3 or that is bonded to the α-carbon atom to which it is attached by a methylene, methine or phenyl radical; andR' is optionally substituted aryl.