145959-21-3

Basic information

• Product Name: 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE
• Synonyms: 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE
• CAS NO: 145959-21-3
• Molecular Formula: C₉H₁₀ClNO₂
• Molecular Weight: 199.63
• Mol File: 145959-21-3.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 335.885°C at 760 mmHg
• Flash Point: 156.938°C
• Appearance: /
• Density: 1.224g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE(145959-21-3)
• EPA Substance Registry System: 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE(145959-21-3)

Safety Data

• Hazardous Substances Data: 145959-21-3(Hazardous Substances Data)

Usage

Uses

3-Chloro-N-methoxy-N-methylbenzamide is an intermediate in the synthesis of ketamine related compounds with potential anesthetic properties.

InChI:InChI=1/C9H10ClNO2/c1-11(13-2)9(12)7-4-3-5-8(10)6-7/h3-6H,1-2H3

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 618-46-2 m-Chlorobenzoyl chloride 
• 201230-82-2 carbon monoxide 
• 625-99-0 3-iodochlorobenzene 
• 535-80-8 3-chlorobenzoate 
• 873-63-2 m-chlorobenzyl alcohol 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 63503-60-6 3-chlorophenylboronic acid 
• 30289-28-2 N-methoxy-N-methylcarbamoyl chloride 

Downstream Products

• 365427-96-9 1-(3-chlorophenyl)-2-(2-fluoro-4-pyridyl) ethanone 
• 51949-06-5 1-(3-chlorophenyl)-3-(dimethylamino)propan-1-one 
• 1385033-52-2 3-(3-chlorobenzoyl)benzonitrile 
• 1314314-59-4 (3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(3-(3-chlorobenzoyl)benzylidene)piperazine-2,5-dione 
• 1267636-78-1 3-(3-chlorobenzoyl)benzaldehyde 
• 1394949-25-7 tert-butyl 5-(3-chlorophenyl)-3,5-dioxopentanoate 
• 7498-66-0 (3-chlorophenyl)(4-chlorophenyl)methanone 
• 42330-59-6 (2-chloropyrid-3-yl)methanol 
• 18370-10-0 3-chloro-N-methyl-benzamide 

Relevant articles and documents

Rhoda-Electrocatalyzed Bimetallic C?H Oxygenation by Weak O-Coordination

Rhodium-electrocatalyzed arene C?H oxygenation by weakly O-coordinating amides and ketones have been established by bimetallic electrocatalysis. Likewise, diverse dihydrooxazinones were selectively accessed by the judicious choice of current, enabling twofold C?H functionalization. Detailed mechanistic studies by experiment, mass spectroscopy and cyclovoltammetric analysis provided support for an unprecedented electrooxidation-induced C?H activation by a bimetallic rhodium catalysis manifold.

Iron-Catalyzed, Iminyl Radical-Triggered Cascade 1,5-Hydrogen Atom Transfer/(5+2) or (5+1) Annulation: Oxime as a Five-Atom Assembling Unit

By integration of iminyl radical-triggered 1,5-hydrogen atom transfer and (5+2) or (5+1) annulation processes, a series of structurally novel and interesting azepine and spiro-tetrahydropyridine derivatives have been successfully prepared in moderate to good yields. This method utilizes FeCl2 as the catalyst and readily available oximes as five-atom units, while showcasing broad substrate scope and good functional group compatibility. The annulation products can be easily converted into many valuable compounds. Moreover, DFT calculation studies are performed to provide some insights into the possible reaction mechanisms for the (5+2) and (5+1) annulations.

CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.