7508-21-6

Basic information

• Product Name: 4-(naphthalen-2-yl)morpholine
• CAS NO: 7508-21-6
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.275
• Mol File: 7508-21-6.mol
• Article Data: 55

Chemical Properties

• Boiling Point: 380.5°C at 760 mmHg
• Flash Point: 112.1°C
• Density: 1.141g/cm³
• Vapor Pressure: 5.41E-06mmHg at 25°C
• Refractive Index: 1.623
• CAS DataBase Reference: 4-(naphthalen-2-yl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(naphthalen-2-yl)morpholine(7508-21-6)
• EPA Substance Registry System: 4-(naphthalen-2-yl)morpholine(7508-21-6)

Safety Data

• Hazardous Substances Data: 7508-21-6(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 135-19-3 β-naphthol 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 3857-83-8 2-naphthyl triflate 
• 7385-85-5 naphthalen-2-yl tosylate 
• 53952-98-0 2-(prop-2′-ynyl)benzaldehyde 
• 1503-86-2 2-naphthyl pivalate 
• 580-13-2 2-bromonaphthalene 
• 108715-76-0 4-(6-methoxynaphthalen-2-yl)morpholine 
• 1145-08-0 naphthalen-2-yl N,N-dimethylsulfamic acid 
• 93-04-9 2-Methoxynaphthalene 
• 16519-26-9 diethyl naphthalen-2-yl phosphate 
• 7657-86-5 tri(naphthalen-2-yl) phosphate 

Downstream Products

• 1331748-60-7 2,2'-dimorpholino-1,1'-binaphthyl 
• 91-20-3 naphthalene 

Relevant articles and documents

Synthesis of biaryl tertiary amines through Pd/norbornene joint catalysis in a remote C-H amination/Suzuki coupling reaction

Here, we report on an efficient palladium/norbornene-catalyzed domino reaction of aryl halide, O-acyl hydroxylamine (R1R2N-OBz), and aromatic pinacol boronate (R-Bpin), selectively affording a series of biaryl tertiary amines in good to high yields with excellent functional group tolerance. This catalytic reaction provides a new opportunity for the convergent synthesis of biaryl amines from easily accessible starting materials.

Electrochemical Cross-Dehydrogenative Aromatization Protocol for the Synthesis of Aromatic Amines

The introduction of amines onto aromatics without metal catalysts and chemical oxidants is synthetically challenging. Herein, we report the first example of an electrochemical cross-dehydrogenative aromatization (ECDA) reaction of saturated cyclohexanones and amines to construct anilines without additional metal catalysts and chemical oxidants. This reaction exhibits a broad scope of cyclohexanones including heterocyclic ketones, affording a variety of aromatic amines with various functionalities, and shows great potential in the synthesis of biologically active compounds.

Coupling of Alternating Current to Transition-Metal Catalysis: Examples of Nickel-Catalyzed Cross-Coupling

The coupling of transition-metal to photoredox catalytic cycles through single-electron transfer steps has become a powerful tool in the development of catalytic processes. In this work, we demonstrated that transition-metal catalysis can be coupled to al

S(vi) in three-component sulfonamide synthesis: Use of sulfuric chloride as a linchpin in palladium-catalyzed Suzuki-Miyaura coupling

Sulfuric chloride is used as the source of the -SO2- group in a palladium-catalyzed three-component synthesis of sulfonamides. Suzuki-Miyaura coupling between the in situ generated sulfamoyl chlorides and boronic acids gives rise to diverse sulfonamides in moderate to high yields with excellent reaction selectivity. Although this transformation is not workable for primary amines or anilines, the results show high functional group tolerance. With the solving of the desulfonylation problem and utilization of cheap and easily accessible sulfuric chloride as the source of sulfur dioxide, redox-neutral three-component synthesis of sulfonamides is first achieved. This journal is