75081-40-2

Basic information

• Product Name: (+/-)2-AMINO-CYCLOHEXANECARBOXYLIC ACID
• Synonyms: RARECHEM AK HD C015;2-AMINO-1-CYCLOHEXANECARBOXYLIC ACID;(+/-)2-AMINO-CYCLOHEXANECARBOXYLIC ACID;(-2-Amino-cyclohexanecarboxylicacid98%;Cyclohexanecarboxylic acid, 2-amino- (7CI,9CI);(1R)-2β-Amino-1β-cyclohexanecarboxylic acid;(1R,2S)-2-Aminocyclohexane-1-carboxylic acid
• CAS NO: 75081-40-2
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.18
• Product Categories: AMINOACID;pharmacetical
• Mol File: 75081-40-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 280 °C at 760 mmHg
• Flash Point: 123.1 °C
• Appearance: /
• Density: 1.133 g/cm³
• Vapor Pressure: 0.00103mmHg at 25°C
• Refractive Index: 1.503
• Storage Temp.: 2-8°C
• PKA: pK1: 3.56(+1);pK2: 10.21(0) (25°C)
• CAS DataBase Reference: (+/-)2-AMINO-CYCLOHEXANECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)2-AMINO-CYCLOHEXANECARBOXYLIC ACID(75081-40-2)
• EPA Substance Registry System: (+/-)2-AMINO-CYCLOHEXANECARBOXYLIC ACID(75081-40-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 75081-40-2(Hazardous Substances Data)

Usage

General Description

(+/-)2-Amino-Cyclohexanecarboxylic Acid, also known as cis/trans 2-Aminocyclohexanecarboxylic acid, represents a combination of the cis and trans isomers of 2-Aminocyclohexanecarboxylic acid. This chemical, which is an amino acid, has both a carboxyl group (-COOH) and an amino group (-NH2) bonded to the same carbon atom. Its structural formula includes a cyclohexane, a six-membered ring of carbon atoms. It exists as a white or almost white crystalline powder and is used primarily in scientific research, specifically in studies involving enzyme stereospecificity and the synthesis of polypeptides. It demonstrates properties typical of amino acids, including the ability to act as a base or an acid, depending on the pH of the environment. Furthermore, being an amino acid, it is essential for protein synthesis.

InChI:InChI=1/C7H13NO2/c8-6-4-2-1-3-5(6)7(9)10/h5-6H,1-4,8H2,(H,9,10)/t5-,6-/m0/s1

Upstream product

• 26693-58-3 (-)-(R,R)-N-benzoyl-trans-2-aminocyclohexanecarboxylic acid 
• 26849-62-7 trans-2-amino-1-cyclohexyl carboxylic acid ethyl ester 
• 267230-48-8 (1R,2R)-2-(benzyloxycarbonylamino)cyclohexylcarboxylic acid 
• 1346773-51-0 (1R,2R)-2-((R)-1-Phenyl-ethylamino)-cyclohexanecarboxylic acid ethyl ester; hydrochloride 
• 24716-94-7 (1S,2S)-2-aminocyclohexanecarboxylic acid ethyl ester 
• 1346773-51-0 (1S,2S)-ethyl 2-((S)-1-phenylethylamino)cyclohexanecarboxylate hydrochloride 
• 118-92-3 anthranilic acid 
• 7732-18-5 water 
• 123-51-3 i-Amyl alcohol 
• 170623-28-6 3,4-dihydro-3-[(S)-α-methylbenzyl]-4-quinazolinone 
• 783371-72-2 2-amino-N-[(S)-α-methylbenzyl]-benzamide 
• 532977-50-7 (1R,2R)-2-((R)-1-Phenyl-ethylamino)-cyclohexanecarboxylic acid 
• 233661-54-6 (1R,2R)-2-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid 
• 856343-59-4 dodecahydro-dibenzo[b,f][1,5]diazocine-6,12-dione 

Downstream Products

• 1089855-81-1 2-(2,4-dinitro-anilino)-cyclohexanecarboxylic acid 
• 1654-67-7 (1R)-trans-2-hydroxy-cyclohexanecarboxylic acid 
• 312965-07-4 (S,S)-trans-N-(9-fluorenylmethoxycarbonyl)-2-aminocyclohexanecarboxylic acid 
• 929602-82-4 2-[(2-hydroxy-5-chloro-benzyl)amino]cyclohexane-1-carboxylic acid 
• 1379691-06-1 (1S,2S)-2-(benzothiazol-2-ylamino)cyclohexylmethanol 
• 213993-31-8 (1S,2S)-2-amino-cyclohexylmethanol 
• 96093-56-0 (-)-(1R,2R)-2-(2,4-Dinitroanilino)cyclohexanecarboxylic acid 
• 16524-13-3 2-benzoylamino-cyclohexanecarboxylic acid 
• 1259278-91-5 (1S,2S)-2-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarboxylic acid 
• 1259279-46-3 (1S,2S)-2-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)-N-ethylcyclohexanecarboxamide 

Relevant articles and documents

Selective hydrogenation of benzoic acid to cyclohexane carboxylic acid over microwave-activated Ni/carbon catalysts

High yields of cyclohexane carboxylic acids were obtained by direct hydrogenation of aromatic carboxylic acids over different Ni/carbon catalysts having distinctive surface properties. The catalysts were characterized by SEM, TEM, H2-TPR and N2 adsorption isotherms for the determination of BET surface area and porosity. The hydrogenation reaction was carried out in batch pressure reactor in gas-liquid phase at 200 °C. High selectivity (100%) of cyclohexane carboxylic acids at 86.2 mol% conversion of benzoic acid was achieved over microwave-activated biochar supported non-precious metal Ni catalyst. The 10%Ni/CSC-b catalyst has been investigated for hydrogenation of benzoic acid to cyclohexane carboxylic acids and shown little deactivation in stability test. The effects of Ni loading, high dispersion of Ni species, appropriate power of microwave heating and strong interaction of Ni species with carbon are of benefit to the reaction.

Isothiourea-mediated asymmetric O- to C-carboxyl transfer of oxazolyl carbonates: Structure-selectivity profiles and mechanistic studies

The structural motif within a series of tetrahydropyrimidine-based isothioureas necessary for generating high asymmetric induction in the asymmetric Steglich rearrangement of oxazolyl carbonates is fully explored, with crossover and dynamic 19F NMR experiments used to develop a mechanistic understanding of this transformation. Copyright

Synthesis and characterisation of helical β-peptide architectures that contain (S)-β3-HDOPA(crown ether) derivatives

A new set of β-amino acids that carry various crown ether receptors on their side chains of the general formula (S)-β3-HDOPA(crown ether) (HDOPA: homo-3,4-dihydroxyphenylalanine; (crown ether): [15]crown-5 ([15-C-5]), [18]crown-6 ([18-C-6]), [21]crown-7 ([21-C-7]), 1,2-Benzo-[24]crown- 8 ([Benzo-24-C-8]) and (R)-Binol-[20]crown-6 ([(R)-Binol-20-C-6])) was prepared. Peptides that are based on these new crowned β-amino acids combined with (1S,2S)-ACHC (2-aminocyclohexanecarboxylic acid), which is known to be a potent 314-helix inducer, to the hexamer level, with two crowned residues at the i and i+3 posi_tions of the main-chain, were synthesized in solution by stepwise coupling using Boc-Na-protection (Boc: tert-butoxycarbonyl) and the EDC/HOAt Cactivation method. Their conformational analysis was performed by using FTIR absorption, NMR and CD spectroscopy techniques. Our results are in full agreement with a 314-helix conformation.