122763-50-2

Upstream product

• 186581-53-3 diazomethane 
• 32384-13-7 α-apopicropodophyllic acid 
• 75101-87-0 dimethyl 1,4-epoxy-1,2,3,4-tetrahydro-6,7-(methylenedioxy)-1-(1,2-cis)-(3',4',5'-trimethoxyphenyl)-2,3-cis-naphthalenedicarboxylate 
• 76886-74-3 C₂₄H₂₂O₁₀ 
• 74879-25-7 -3,4-methylenedioxybenzaldehyde dimethyl acetal 
• 86301-75-9 dimethyl 4-(3,4-trans)-hydroxy-6,7-(methylenedioxy)-1-(1,2-cis)-(3',4',5'-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-2,3-cis-dicarboxylate 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 74879-22-4 6-bromobenzo-1,3-dioxole-5-carboxaldehyde dimethyl acetal 
• 120-57-0 piperonal 
• 116097-18-8 6,7-methylenedioxy-1-(3',4',5'-trimethoxyphenyl)-2-benzopyran-3-one 
• 1256-91-3 methyl isopicropodophyllate 

Downstream Products

• 1256-91-3 methyl isopicropodophyllate 
• 1643-12-5 (5S,6S,7S)-7-Hydroxymethyl-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester 
• 477-51-0 (5S,5aS,8aR)-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3′,4’:6,7]naphtho[2,3-d][1,3]-dioxol-6(5aH)-one 
• 77519-37-0 9-hydroxy-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 

Relevant academic research and scientific papers

Synthesis of Podophyllotoxin

The alkene (2) obtained directly from the reaction of dimethyl maleate with the pyrone (1) is converted into (+/-)-podophyllotoxin (12) in seven steps and 24percent overall yield; novel steps include the epimerisation of (9) at C-3 using 1,8-diazabicyclo

Synthesis of (+/-)-4-Deoxypodophyllotoxin, (+/-)-Podophyllotoxin and (+/-)-Epipodophyllotoxin

6,7-Methylenedioxy-1-(3',4',5'-trimethoxyphenyl)-2-benzopyran-3-one 1 and dimethyl fumarate in acetonitrile give mostly the C-2 exo-CO2Me adduct 4 which is transformed in four steps into epipodophyllotoxin 10a.Attempted addition of dimethyl maleate to 1 p

Comprehensive Synthetic Route to Eight Diastereomeric Podophyllum Lignans

An oxabicyclo compound, 9, prepared in 47percent yield through an isobenzofuran intermediate was converted with excellent regio- and stereocontrol to eight (+/-)-lignan lactones of the podophyllotoxin series.One of the eight, epiisopicropodophyllin, 36, t