7515-38-0

Basic information

• Product Name: (3E)-4-phenylbut-3-en-1-amine
• Synonyms: (3E)-4-Phenylbut-3-en-1-amin; 3-Buten-1-amine, 4-phenyl-, (3E)-
• CAS NO: 7515-38-0
• Molecular Formula: C₁₀H₁₃N
• Molecular Weight: 147.2169
• Mol File: 7515-38-0.mol

Chemical Properties

• Boiling Point: 263.9°C at 760 mmHg
• Flash Point: 109.7°C
• Density: 0.977g/cm³
• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: (3E)-4-phenylbut-3-en-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (3E)-4-phenylbut-3-en-1-amine(7515-38-0)
• EPA Substance Registry System: (3E)-4-phenylbut-3-en-1-amine(7515-38-0)

Safety Data

• Hazardous Substances Data: 7515-38-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(3E)-4-phenylbut-3-en-1-amine is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique structure and properties make it a valuable component in the development of new drugs and medicines.
Used in Chemical Industry:
(3E)-4-phenylbut-3-en-1-amine serves as a building block in the production of various chemicals. Its versatility allows it to be used in a wide range of chemical processes, contributing to the creation of diverse chemical products.
Used in Research and Development:
(3E)-4-phenylbut-3-en-1-amine is utilized in research and development within the pharmaceutical and chemical industries. Its potential applications in medicinal chemistry and drug discovery make it an important compound for scientists and researchers working on innovative solutions and advancements in these fields.

Upstream product

• 143741-67-7 N-(4-phenyl-3-butenyl)phthalimide 
• 74592-04-4 (E)-2-(4-phenylbut-3-en-1-yl)isoindoline-1,3-dione 
• 14371-10-9 (E)-3-phenylpropenal 
• 85669-63-2 (E)-cinnamyl diethyl phosphate 
• 26121-45-9 (E)-4-phenyl-3-butenamide 
• 100-52-7 benzaldehyde 
• 89996-01-0 (3-aminopropyl)(triphenyl)phosphonium bromide 
• 93652-37-0 4-phenyl-3-butenyl para-toluenesulfonate 

Downstream Products

• 125630-44-6 3-chloro-propionic acid-(4t-phenyl-but-3-enylamide) 
• 39551-07-0 (E)-4-methyl-N-(4-phenylbut-3-en-1-yl)benzenesulfonamide 
• 106814-09-9 N-(E)-(4-phenylbut-3-en-1-yl)acetamide 
• 7515-57-3 Naphthalin-2-sulfonsaeure-<4-phenyl-but-3-en-1-ylester> 
• 7515-41-5 (E)-(4-bromobut-1-en-1-yl)benzene 

Relevant articles and documents

Alkene Oxyamination Using Malonoyl Peroxides: Preparation of Pyrrolidines and Isoxazolidines

Treatment of homoallylic N-tosyl amines or allylic N-tosyl hydroxylamines with 1.5 equiv of a malonoyl peroxide provides a stereoselective method to access functionalized pyrrolidines and isoxazolidines. This metal free alkene oxyamination proceeds in 50-

Convenient route to primary (Z)-allyl amines and homologs

A convenient two-step procedure for the synthesis of primary (Z)-allyl amines, (Z)-homoallyl amines [(Z)-but-3-enylamines], and (Z)-pent-4-enylamines using the Wittig reaction was achieved. The use of nonstabilized ylides from triphenylphosphonium salt, potassium salt, and apolar solvent produced (Z/E)-geometric isomer ratios generally greater than 1.6. The amine moiety was masked using a phtalimide group that was removed successfully in the last step of the process in two different conditions, NH2NH2/EtOH/rt or CH3NH2/EtOH/rt. However, in some cases, reduction of the C = C double bond in the deprotection with hydrazine was concomitantly observed. Copyright Taylor & Francis Group, LLC.

Aza- and oxacarbonylations of allyl phosphates catalyzed by rhodium carbonyl cluster. Selective synthesis of β,γ-unsaturated amides, esters, and acids

Rhodium-catalyzed carbonylation of allyl phosphates under CO (20 atm) at 50 deg C proceeds very efficiently in the presence of amines, alcohols, and water to give the corresponding β,γ-unsaturated amides, esters, and acids, respectively.These carbonylations occur with high regioselectivity at the less substituted carbon of allyl unit to give linear β,υ-unsaturated acid derivatives.

ANOMALOUS STEREOCHEMISTRY IN THE WITTIG REACTION INDUCED BY NUCLEOPHILIC GROUPS IN THE PHOSPHONIUM YLIDE

Reaction of ylides from 3-9 with benzaldehyde show that carboxylate and oxido functionalities proximate to the ylide center promote anomalously high E stereoselectivity in alkene formation.Through the use of α-deuterated ylides 12-14, an internal "trans-selective Wittig" mechanism was ruled out as a principal source of exaggerated E alkene production.