26121-45-9

Upstream product

• 201230-82-2 carbon monoxide 
• 85669-63-2 (E)-cinnamyl diethyl phosphate 
• 25316-59-0 benzyl tri-n-butylammonium bromide 
• 79-06-1 2-propenamide 
• 21087-29-6 trans-3-phenylprop-2-enyl chloride 
• 21040-45-9 Cinnamyl acetate 
• 87802-71-9 (E)-methyl cinnamyl carbonate 
• 144-48-9 iodacetamide 
• 103-64-0 bromostyrene 
• 118575-70-5 trans-styrylacetyl chloride 
• 2243-53-0 trans-styrylacetic acid 
• 7217-71-2 1-phenyl-2-propenyl acetate 
• 77287-34-4 formamide 

Downstream Products

• 1199-98-0 4-phenylbutyramide 
• 1396722-90-9 (E)-4-phenylbut-3-enethioamide 
• 7515-38-0 (E)-4-phenylbut-3-en-1-amine 
• 2243-53-0 trans-styrylacetic acid 

Relevant academic research and scientific papers

Nickel/Photo-Cocatalyzed C(sp2)-H Allylation of Aldehydes and Formamides

Herein we report a nickel/photo-cocatalyzed C(sp2)-H allylation of aldehydes and formamides wherein both allyl acetates and allyl alcohols can be used as the allylating agents. In this reaction, radical-type umpolung of the formyl moiety is enabled by tetrabutylammonium decatungstate as a hydrogen-atom-transfer photocatalyst, whereas nickel serves to cleave the C-O bond of allyl acetates or allyl alcohols. The synergistic effect of these two catalysts provides new access to various β,γ-unsaturated ketones and amides with high selectivities.

Synthesis of α-Arylcarboxylic acid amides from silyl enol ether via migratory Amidation with 2-azido-1,3-dimethylimidazolinium hexafluorophosphate

α-Arylcarboxylic acid amides were synthesized by reacting silyl enol ethers of aryl ketones and 2-azido-1,3-dimethylimidazolinium hexafluorophosphate (ADMP,1). Silyl enol ethers react with ADMP 1 to give N-(α-arylacyl) guanidines via the migration of aryl groups in enol ethers. The products were transformed to the corresponding α-aryl acetamides by treating with LiAlH4.

Histone Deacetylase Inhibitors

This invention relates to generally inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).

HISTONE DEACETYLASE INHIBITORS

This invention relates to generally inhibiting histone deacetylase (HDAC) enzymes (e.g., HDAC1, HDAC2, and HDAC3).

Radical alkenylation of α-halo carbonyl compounds with alkenylindiums

(Chemical equation presented) Alkenylation reaction of α-halo carbonyl compounds with alkenylindiums proceeded via a radical process in the presence of triethylborane. Unactivated alkene moieties as well as a styryl group could be introduced by this metho

Synthesis of allylamides from allyl halides, carbon monoxide, and titanium-nitrogen complexes prepared from molecular nitrogen

4-Phenylbut-3-enamide could be synthesized from corresponding 3-chloroprop-2-enylbenzene, carbon monoxide (1atm), and titanium-nitrogen complexes, prepared from Ti(OiPr)4, Li, TMSCl, and molecular nitrogen (1atm), using a palladium catalyst. The reaction proceeds via transmetalation of the titanium-nitrogen complex to an acylpalladium complex. PtBu3 as a ligand of the palladium catalyst, afforded a good result, and the amounts of Li and TMSCl affected the yield of amide. When the reaction was carried out using a bidentate ligand on the palladium complex under an atmosphere of argon instead of carbon monoxide, an allylamine derivative was obtained.

Vinylation of benzylic quaternary ammonium salts catalyzed by palladium

The palladium-catalyzed vinylation of benzylic tributylammonium salts with a variety of olefins has been studied. A possible free radical mechanism is proposed.

Aza- and oxacarbonylations of allyl phosphates catalyzed by rhodium carbonyl cluster. Selective synthesis of β,γ-unsaturated amides, esters, and acids

Rhodium-catalyzed carbonylation of allyl phosphates under CO (20 atm) at 50 deg C proceeds very efficiently in the presence of amines, alcohols, and water to give the corresponding β,γ-unsaturated amides, esters, and acids, respectively.These carbonylations occur with high regioselectivity at the less substituted carbon of allyl unit to give linear β,υ-unsaturated acid derivatives.