NUCLEOSIDES AND NUCLEOTIDES. PART 27. SOLID PHASE SYNTHESIS OF A TRIDECANUCLEOSIDE DODECAPHOSPHATE CONTAINING THE UNNATURAL BASE 4-AMINO-2(1H)-PYRIDINONE AND OF AN OCTANUCLEOSIDE HEPTAPHOSPHATE FOR THE DETERMINATION OF THE DNA-POLYMERASE SPECIFICITY

Article abstract of DOI:10.1002/hlca.19870700321

The tridecanucleoside dodecaphosphate d-(T-T-Z-C-G-T-C-A-A-A-A-T-C) incorporating the modified nucleoside 4-amino-1-(2'-deoxy-β-ribofuranosyl)-2(1H)-pyridone (Z_d, 1) and the octanucleoside heptaphosphate d(G-A-T-T-T-T-G-A) were synthesized by the solid-phase method using the triester method.The carrier material was a copolymer consisting of styrene with 1 percent divinylbenzene.