75258-07-0

Upstream product

• 7474-93-3 4-acetamido-3-aminophenyl acetate 
• 51-17-2 benzoimidazole 
• 546-67-8 lead(IV) tetraacetate 
• 7403-75-0 N-(4-hydroxy-2-nitrophenyl)-acetamide 
• 108-24-7 acetic anhydride 
• 66927-19-3 2,2-dimethyl-4,5,6,7-tetrahydro-2H-benzimidazole 1,3-dioxide 
• 103-90-2 4-acetaminophenol 
• 50700-49-7 N-acetyl-p-benzoquinoneimine 
• 492-99-9 1,2-cyclohexanedionedioxime 
• 27992-37-6 1-hydroxy-2,2-dimethyl-4,5,6,7-tetrahydrobenzimidazoline 3-oxide 
• 610-81-1 4-hydroxy-2-nitroaniline 
• 2623-33-8 4-acetoxyacetanilide 
• 2243-69-8 4-acetamido-3-nitrophenyl acetate 

Downstream Products

• 75258-08-1 1-hydroxy-3,4-diacetamidobenzene 
• 4053-51-4 2-acetylamino-1,4-benzoquinone 

Relevant academic research and scientific papers

A NEW NITRATION PRODUCT, 3-NITRO-4-ACETAMIDOPHENOL, OBTAINED FROM ACETAMINOPHEN WITH NITROUS ACID

Treatment of acetaminophen with an excess sodium nitrite under mildly acidic to neutral conditions results in smooth formation of new 3-nitro-4-acetamidophenol via N-acetyl-p-benzoquinone imine as an oxidation intermediate, which is a well-known, widely e

Oxidations with Lead Tetraacetate. VI. Oxidations of Benzimidazoles, Benzoxazoles and Benzothiazoles

Benzimidazole is slowly oxidized in the imidazole ring by lead tetraacetate to benzimidazol-2(3H)-one, 1-acetylbenzimidazol-2(3H)-one and N,N'-(o-phenylene)bisacetamide.With excess oxidant, oxidation also occurs in the benzene ring at C5.Benzoxazole is much more reactive and gives a variety of products formed by oxidation of both rings.Benzothiazole is the least reactive system and suffers only minimal oxidation at C2 of the thiazole ring.

PREPARATION AND SOME PROPERTIES OF 2H-IMIDAZOLE 1,3-DIOXIDES, DERIVATIVES OF ALICYCLIC 1,2-DIOXIMES

The corresponding 2H-imidazole 1,3-dioxides were obtained by the reaction of cyclohexanedione and cycloheptanedione 1,2-dioximes with acetone, cyclopentanone, and methyl ethyl ketone.The reactions of these compounds with hydroxylamine hydrochloride, NaBH4, a Grignard reagent, and acetic anhydride in the presence of H2SO4 were studied in the case of 2,2-dimethyl-4,5,6,7-tetrahydro-2H-benzimidazole 1,3-dioxide.Bromination of the latter and 2,2-dimethylcyclohepta-2H-imidazole 1,3-dioxide with N-bromosuccinimide gave the corresponding dibromo derivatives, the bromineatoms in which are replaced by acetoxy and hydroxy groups. 4,7-Dihydroxy-2,2-dimethyl-4,5,6,7-tetrahydro-2H-benzimidazole 1,3-dioxide, which was obtained by oxidation with MnO2, was converted to a quinone, viz., 2,2-dimethyl-4,7-dioxo-4,7-dihydro-2H-benzimidazole 1,3-dioxide.