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Cyclohexanone, 3-(trimethylsilyl)-, also known as 3-(trimethylsilyl)cyclohexanone, is an organic compound with the chemical formula C9H19OSi. It is a colorless liquid that is soluble in organic solvents and has a molecular weight of 173.34 g/mol. Cyclohexanone, 3-(trimethylsilyl)- is a derivative of cyclohexanone, where one of the hydrogen atoms on the cyclohexane ring is replaced by a trimethylsilyl group (Si(CH3)3). The trimethylsilyl group is often used to protect or modify the reactivity of functional groups in organic synthesis. Cyclohexanone, 3-(trimethylsilyl)-, is used in various chemical reactions, particularly in the protection of ketones, and can be synthesized through the reaction of cyclohexanone with trimethylsilyl chloride in the presence of a base. It is an important intermediate in the synthesis of more complex organic molecules and has applications in the pharmaceutical and chemical industries.

7531-60-4

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7531-60-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7531-60-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,5,3 and 1 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 7531-60:
(6*7)+(5*5)+(4*3)+(3*1)+(2*6)+(1*0)=94
94 % 10 = 4
So 7531-60-4 is a valid CAS Registry Number.

7531-60-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-trimethylsilylcyclohexan-1-one

1.2 Other means of identification

Product number -
Other names 3-trimethylsilylcyclohexanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7531-60-4 SDS

7531-60-4Relevant academic research and scientific papers

REAKTION VON TRIS(TRIMETHYLSILYL)ALUMINIUM MIT α, β-UNGESAETTIGTEN CARBONYLVERBINDUNGEN

Altnau, G.,Roesch, L.,Jas, Gerhard

, p. 45 - 46 (1983)

The 1,2- and 1,4-addition of tris(trimethylsilyl)aluminium to α, β-unsaturated carbonyl compounds is described.

Diastereoselectivity control of the radical carboazidation of substituted methylenecyclohexanes

Cren, Sylvaine,Schar, Pascal,Renaud, Philippe,Schenk, Kurt

supporting information; experimental part, p. 2942 - 2946 (2009/09/06)

A systematic study of the diastereoselectivity of the radical carboazidation of methylenecyclohexane derivatives is presented. Several substitution patterns leading to a high level of stereocontrol have been identified. Axial attack is the preferred reaction pathway for cyclohexyl radicals, and excellent stereoselectivities can be obtained by introducing an axial substitutent at position 2. In this case, a second equatorial substituent at position 2 may be tolerated without a large detrimental effect on the diastereoselectivity. Finally, a high level of equatorial attack is observed with a very bulky substituent at position 2.

Silicon and tin-directed Tiffeneau-Demjanov reaction

Chow, Leonie,McClure, Melanie,White, Jonathan

, p. 648 - 650 (2007/10/03)

Silicon and tin substituents surprisingly have only a moderate directing effect on the Tiffeneau-Demjanov reaction. The low selectivity is rationalised as being due to the reactive nature of the diazonium ion leaving group, the weaker oxydiazene leaving g

Electronic and steric effects of silyl groups in silicon-directed Norrish type cleavages

Hwu, Jih Ru,Chen, Buh-Luen,Lin, Chien-Fu,Murr, Brown L.

, p. 198 - 201 (2007/10/03)

Sterically congested cis-2-(t-butyl)-3-(organosilyl)cyclohexanones were irradiated with UV light to give a mixture of Norrish type I and II products, as well as the corresponding trans-2-(t-butyl)-3- (organosilyl)cyclohexanones. In comparison with the trans isomers, the quantum yields and rate constants of the photolytic reactions were greater for the cis isomers.

Alkoxides of o-silyl benzyl alcohols in cleavage reactions: Approaches to benzyl and silyl anion equivalents

Hudrlik, Paul F.,Arango, Jose O.,Hijji, Yousef M.,Okoro, Cosmas O.,Hudrlik, Anne M.

, p. 1421 - 1427 (2007/10/03)

The alkoxides of o-silyl benzyl alcohols 4 undergo cleavage reactions under mild conditions allowing transfer of a benzyl or silyl group to an electrophile. Reactions 3a → 8, and 3c or 4c → 11 illustrate their potential as benzyl and silyl anion equivalents.

Influence of β-Silyl Groups in Cycloalkanones on the Norrish Type I and Type II Cleavages

Hwu, Jih Ru,Chen, Buh-Luen,Huang, Li Wen,Yang, Tu-Hsin

, p. 299 - 300 (2007/10/02)

The Norrish type I cleavage overwhelms the type II cleavage in the photolysis of α-alkylcycloalkanones bearing an SiMe3, SiMe2Ph, SiMePh2, or SiPh3 group at the β-position, of which the quantum yields are often greater than those of the non-silylated cycl

3-Metallated enamines XI. Transmetallation of 3-Stannylated enamines - A new method to generate 1-aminoallyllithium compounds

Ahlbrecht,Weber

, p. 1018 - 1025 (2007/10/02)

The transmetallation of 3-stannylated enamines, 1-morpholino-3-(trialkylstannyl)cycloalk-1-enes and 3-morpholino-5-(tributylstannyl)hex-3-ene, with butyllithium is a new and general way to generate s1-aminoallyllithium compounds. Stabilization by aromatic substituents is not further necessarily as in the case of preparation by deprotonation and even the thermodynamically less stable exoamino derivatives are accessible. Therefore homoenolate-equivalents of cyclic ketones are made available. Thus, the corresponding 3-alkylated or 3-silylated cycloalkanones and alken-3-ones were prepared via the 1-morpholinoallyllithium compounds.

Lewis Acid-induced Reaction of Silicon-containing Stannyl Ketones and Its Application to the Synthesis of (+)-β-Cuparenone

Sato, Tadashi,Hayashi, Masahito,Hayata, Toshihiro

, p. 4099 - 4114 (2007/10/02)

Lewis acids activated only stannyl group in the silicon-containing stannyl ketones.The silyl group neither participated in the reaction directly, nor excerted any influences upon the reaction mode of the stannyl group.The reaction was applied for the synt

γ-Silicon Stabilization of Carbonium Ions in Solvolysis. 4. Solvolysis of cis- and trans-3-(Trimethylsilyl)cyclohexyl and -3-tert-Butylcyclohexyl p-Bromobenzenesulfonates

Shiner, V.J.,Ensinger, Mark W.,Kriz, George S.,Halley, Karen A.

, p. 653 - 661 (2007/10/02)

The solvolyses of cis- and trans-3-(trimethylsilyl)cyclohexyl and -3-tert-butylcyclohexyl p-bromobenzenesulfonates (1-4) have been examined in several ethanol- and trifluoroethanol-water solvent mixtures.The α- and β-deuterium kinetic isotope effects have

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