75332-44-4

Basic information

• Product Name: 3,4-DIETHOXYBENZOIC ACID ETHYL ESTER
• Synonyms: ETHYL 3,4-DIETHOXYBENZOATE;3,4-DIETHOXYBENZOIC ACID ETHYL ESTER;3,4-DIETHOXYETHYLBENZOATE;RARECHEM AL BI 0251
• CAS NO: 75332-44-4
• Molecular Formula: C₁₃H₁₈O₄
• Molecular Weight: 238.28
• Product Categories: Aromatic Esters
• Mol File: 75332-44-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 54-58 °C(lit.)
• Boiling Point: 331.4°C at 760 mmHg
• Flash Point: 230 °F
• Appearance: /
• Density: 1.059g/cm³
• Vapor Pressure: 0.000156mmHg at 25°C
• Refractive Index: 1.492
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3,4-DIETHOXYBENZOIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIETHOXYBENZOIC ACID ETHYL ESTER(75332-44-4)
• EPA Substance Registry System: 3,4-DIETHOXYBENZOIC ACID ETHYL ESTER(75332-44-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 75332-44-4(Hazardous Substances Data)

Usage

General Description

3,4-Diethoxybenzoic acid ethyl ester is a chemical compound with the molecular formula C12H16O4. It is an ester formed from the reaction of 3,4-diethoxybenzoic acid and ethanol. 3,4-DIETHOXYBENZOIC ACID ETHYL ESTER is commonly used as a reagent in organic synthesis and pharmaceutical research. It has applications in the production of pharmaceuticals, fragrances, and fine chemicals. It is a colorless to pale yellow liquid with a sweet, floral odor and is slightly soluble in water. 3,4-Diethoxybenzoic acid ethyl ester is known to have low acute toxicity, but exposure to this compound should be limited to prevent irritation and potential health risks.

InChI:InChI=1/C13H18O4/c1-4-15-11-8-7-10(13(14)17-6-3)9-12(11)16-5-2/h7-9H,4-6H2,1-3H3

Upstream product

• 139-85-5 3,4-dihydroxybenzaldehyde 
• 2029-94-9 3,4-diethoxybenzaldehyde 
• 64-17-5 ethanol 
• 5409-31-4 3,4-diethoxybenzoic acid 
• 74-96-4 ethyl bromide 
• 3943-89-3 Ethyl protocatechuate 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 75-03-6 ethyl iodide 

Downstream Products

• 1351800-46-8 ethyl 2-bromo-4,5-diethoxybenzoate 
• 1351800-47-9 2-(2-bromo-4,5-diethoxyphenyl)propan-2-ol 
• 1351800-48-0 1-bromo-4,5-diethoxy-2-(1-methylethenyl)benzene 
• 1351800-49-1 4,5-diethoxy-2-(1-methylethenyl)benzonitrile 
• 1351800-62-8 1-[3-(tert-butyl)-4-methoxy-5-(morpholin-4-yl)phenyl]-2-(5,6-diethoxy-1,3-dihydro-3-imino-1,1-dimethyl-1H-isoindol-2-yl)ethanone hydrobromide 
• 1351800-64-0 ethyl 2-cyano-4,5-diethoxybenzoate 
• 1351800-67-3 2-(2-aminomethyl-4,5-diethoxyphenyl)propan-2-ol 
• 380482-31-5 3,4-diethoxybenzohydrazide 
• 1494496-36-4 C₁₅H₂₄O₃ 
• 2050-46-6 1,2-diethoxybenzene 
• 570431-14-0 (2-chloromethyl-6,7-diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine 
• 716314-61-3 2-bromo-1-[3-(6,7-diethoxy-quinazolin-4-ylamino)-phenyl]-ethanone 
• 774532-51-3 1-[3-(6,7-diethoxy-quinazolin-4-ylamino)-phenyl]-ethanone 

Relevant articles and documents

Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus

Chikungunya virus is a re-emerging arbovirus transmitted to humans by Aedes mosquitoes, responsible for an acute febrile illness associated with painful and debilitating arthralgia, which can persist for several months or become chronic. Over the past few years, infection with this virus has spread worldwide with a previously unknown virulence. No specific antiviral treatments nor vaccines are currently available against this important pathogen. Starting from the structure of a class of selective anti-CHIKV agents previously identified in our research group, different modifications to this scaffold were rationally designed, and 69 novel small-molecule derivatives were synthesised and evaluated for their inhibition of Chikungunya virus replication in Vero cells. Further structure-activity relationships associated with this class of antiviral agents were elucidated for the original scaffolds, and novel antiviral compounds with EC50 values in the low micromolar range were identified. This work provides the foundation for further investigation of these new structures as antivirals against Chikungunya virus.

QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF

Compounds according to formula (I), compositions and methods are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by RAF kinases. Formula (I): or a pharmaceutically acceptable salt, solvate, clathrate of hydrate thereof, wherein X is O or S(O)t; Ra is O or S.