7536-61-0

Upstream product

• 4530-20-5 BOC-glycine 
• 95-95-4 2,4,5-trichlorophenol 
• 108034-67-9 1,2,2,2-tetrachloroethyl 2,4,5-trichlorophenyl carbonate 
• 244633-30-5 4-nitro-benzenesulfonic acid 2,4,5-trichloro-phenyl ester 

Downstream Products

• 66831-21-8 2-[2-(2-tert-butoxycarbonylamino-acetylamino)-acetylamino]-3-phenyl-propionic acid benzyl ester 
• 70035-45-9 N-tert-Butyloxycarbonyl-glycyl-glycyl-L-phenylalanyl-L-methionin-methylester 
• 69872-63-5 N-(tert-butyloxycarbonyl)glycyl-L-phenylalanyl-L-methionine methyl ester 
• 80164-29-0 N-t-butoxycarbonylglycylglycyl-L-phenylalanyl-L-leucine methyl ester 
• 94776-16-6 Boc-Tyr-Gly-Gly-Phe-Met-ONBzl 
• 94776-14-4 Boc-Gly-Phe-Met-ONBzl 
• 171807-14-0 N-(N-(N-(N-(1,1-dimethylethoxycarbonyl)glycyl)phenylalanyl)leucyl)glycine N-(2-(N(phenylmethoxycarbonyl)sarcosylamino)ethyl)amide 

Relevant academic research and scientific papers

Synthesis of aryl esters of protected amino acids from aryl sulfonates

Aryl esters of Boc- and Fmoc-protected amino acids derived from electron-deficient phenols have been prepared in good yields from aryl 4- nitrobenzenesulfonates in the presence of 1-hydroxy-benzotriazole as catalyst.

Biologically compatible linear block copolymers of polyalkylene oxide and peptide units

A linear block copolymer comprising units of an alkylene oxide, linked to units of peptide via a linking group comprising a --CH2 CHOHCH2 N(R)-- moiety, is useful as an imaging agent, drug, prodrug or as a delivery system for imaging agents, drugs or prodrugs.

Novel Preparation of N-Protected Amino Acid Active Esters Using 1,2,2,2-Tetrachloroethyl Carbonates

1,2,2,2-Tetrachloroethyl chloroformate reacts with substituted phenols or N-hydroxy imides to yield crystalline and stable mixed aryl or oximido tetrachloroethyl carbonates.When allowed to react with an N-protected amino acid derivative, these compounds proved to be efficient for the syntheses of the corresponding active esters.A series of active esters including p-nitrophenol, trichlorophenol, pentafluorophenol, and N-hydroxysuccinimide derivatives were prepared by this new procedure.