75371-59-4Relevant academic research and scientific papers
Copper-promoted Chan-Lam coupling between enaminones and aryl boronic acids
Duan, Xiyan,Liu, Ning,Liu, Kun,Song, Yakun,Wang, Jia,Mao, Xianhua,Xu, Weidong,Yang, Shijie,Li, Huixian,Ma, Junying
supporting information, p. 4187 - 4190 (2018/10/24)
A novel copper-promoted N-arylation of enaminones with aromatic boronic acids has been developed, which provides an efficient way to synthesize N-aryl enaminones with a broad substrate scope and excellent functional group compatibility. The N-aryl enaminones could be converted into a series of highly valuable building blocks and bioactive compounds. Notably, in comparison with traditional methods, this alternative approach provides accesses to N-aryl enaminones bearing multiple aromatic rings.
Iodine/Copper Iodide-Mediated C-H Functionalization: Synthesis of Imidazo[1,2-a]pyridines and Indoles from N-Aryl Enamines
Liu, Jing,Wei, Wei,Zhao, Ting,Liu, Xuanyu,Wu, Jie,Yu, Wenquan,Chang, Junbiao
, p. 9326 - 9336 (2016/10/14)
A practical intramolecular C-H functionalization reaction of N-aryl enamines has been carried out with molecular iodine (I2) as the sole oxidant in the presence of copper iodide (CuI). The efficient and versatile synthetic method described here
A metal-free multicomponent cascade reaction for the regiospecific synthesis of 1,5-disubstituted 1,2,3-triazoles
Cheng, Guolin,Zeng, Xiaobao,Shen, Jinhai,Wang, Xuesong,Cui, Xiuling
supporting information, p. 13265 - 13268 (2014/01/06)
About specifics: A method for the regiospecific synthesis of the title compounds through an unprecedented Michael addition/deacylative diazo transfer/cyclization sequence has been established. The simple and practical method can be used for the modification of primary amines including chiral α-amines. The process involves the formation three covalent bonds and the cleavage of two covalent bonds (see scheme, Ts=4-toluenesulfonyl).
Copper-catalyzed C-C bond formation through C-H functionalization: Synthesis of multisubstituted indoles from N-aryl enaminones
Bernini, Roberta,Fabrizi, Giancarlo,Sferrazza, Alessio,Cacchi, Sandro
supporting information; experimental part, p. 8078 - 8081 (2010/01/16)
A variety of functionalities, including the whole range of halogen substituents, are tolerated in the title reaction, an intramolecular approach for the construction of a multisubstituted indole skeleton from readily available enaminones (see scheme; phen=1,10-phenanthroline). The indole products are also prepared directly in high yield from α, β-ynones and primary amines.
1,3-DIPOLAR CYCLOADDITION OF ARYL AZIDES TO 1-ARYL-3-PHENYLPROP-2-YN-1-ONES
Fouli, Fouli Abd El-Rahim,Shaban, Mohamed El-Badry,El-Nagdy, El-Sayed Ibrahim,Youssef, Ahmed Said Ahmed
, p. 785 - 792 (2007/10/02)
Aryl azides (IIa-c) condense with 1-aryl-3-phenylprop-2-yn-1-ones (Ia-c) to give a mixture of 1-aryl-4-aroyl-5-phenyl- (IIIa-h) (predominant), 1-aryl-5-aroyl-4-phenyl- (IVa-h) (minor) -1,2,3-triazoles, as isomeric products, and 3-(arylamino)-1-aryl-3-phenylprop-2-en-1-ones (V).The structural assignments of the products were based on (1)H-NMR, mass, infrared and electronic spectra, as well as analytical data.
Reactions of Primary and Secondary Aromatic Amines with Aroylphenylacetylenes and Configurational Assignments of the Adducts
Fouli, F. A.,Beshay, A. D.
, p. 410 - 412 (2007/10/02)
The reaction of aroylphenylacetylenes (Ia-c) with aniline and other primary and secondary aromatic amines in a protic solvent (ethanol) gives rise to only (Z)-isomers (IIa-s) of the adducts.However, the reaction of benzoylphenylacetylene (Ia) with aniline
