7538-44-5

Usage

Uses

Used in Surface Modification Industry:
BIS(2-HYDROXYETHYL)-3-AMINOPROPYLTRIETHOXYSILANE is used as a coupling agent for promoting strong adhesion between organic and inorganic materials. Its application reason is due to its ability to form covalent bonds with inorganic surfaces and hydrogen bonds with organic materials, thus improving the compatibility and interfacial properties of the materials.
Used in Nanoporous Silica Functionalization:
BIS(2-HYDROXYETHYL)-3-AMINOPROPYLTRIETHOXYSILANE is used as a functionalizing agent for nanoporous silica (SBA-15). The application reason is to introduce hydroxyethyl and aminopropyl groups onto the silica surface, which can enhance the material's properties, such as hydrophilicity, and enable further chemical modifications or the attachment of specific functional groups for various applications, including catalysis, drug delivery, and sensing.

Synthetic route

(3-chloropropyl)triethoxysilane (5089-70-3) + 2,2'-iminobis[ethanol] (111-42-2) → 3-[bis(2-hydroxyethyl)amino]propyltriethoxysilane (7538-44-5)

Conditions	Yield
With potassium iodide In dimethyl sulfoxide at 120℃; Inert atmosphere;

3-[bis(2-hydroxyethyl)amino]propyltriethoxysilane (7538-44-5) + ethanol (64-17-5) + trimethylaluminum (75-24-1) → C15H34AlNO6Si

Conditions	Yield
In toluene at 0℃; for 4h; Inert atmosphere; Schlenk technique;	95%

3-[bis(2-hydroxyethyl)amino]propyltriethoxysilane (7538-44-5) + ethanol (64-17-5) + dibutylmagnesium (1191-47-5) → C14H33MgNO6Si

Conditions	Yield
In n-heptan1ol at 0 - 20℃; for 4h; Inert atmosphere; Schlenk technique;	91%

3-[bis(2-hydroxyethyl)amino]propyltriethoxysilane (7538-44-5) + ethanol (64-17-5) + aluminum isopropoxide (555-31-7) → C15H34AlNO6Si

Conditions	Yield
In toluene at 0℃; for 4h; Inert atmosphere; Schlenk technique;	88%

titanium(IV) isopropylate (546-68-9) + 3-[bis(2-hydroxyethyl)amino]propyltriethoxysilane (7538-44-5) → C19H43NO7SiTi

Conditions	Yield
In ethanol; dichloromethane at 20℃; for 4h; Inert atmosphere; Schlenk technique;

3-[bis(2-hydroxyethyl)amino]propyltriethoxysilane (7538-44-5) → C23H43N5O9Si

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 35 h / 80 °C / Inert atmosphere 1.2: 0.75 h / 150 °C / Inert atmosphere 2.1: water / 2 h / 85 °C View Scheme

3-[bis(2-hydroxyethyl)amino]propyltriethoxysilane (7538-44-5) → C35H65N5O9Si2

Conditions	Yield
Multi-step reaction with 3 steps 1.1: 35 h / 80 °C / Inert atmosphere 1.2: 0.75 h / 150 °C / Inert atmosphere 2.1: water / 2 h / 85 °C 3.1: ethanol / 3 h / 40 °C View Scheme

1,6-dicyanatohexane + 3-[bis(2-hydroxyethyl)amino]propyltriethoxysilane (7538-44-5) → C29H55N5O9Si

Conditions	Yield
Stage #1: 1,6-dicyanatohexane; 3-[bis(2-hydroxyethyl)amino]propyltriethoxysilane at 80℃; for 35h; Inert atmosphere; Stage #2: With tin(IV) chloride at 150℃; for 0.75h; Inert atmosphere;

Upstream product

• 5089-70-3 (3-chloropropyl)triethoxysilane 
• 111-42-2 2,2'-iminobis[ethanol] 

Relevant academic research and scientific papers

Preparation method of organic silicon toughened isocyanate resin based on chemical bonding (by machine translation)

Under the catalysis of potassium iodide, hydroxyl is introduced, hydroxyl is introduced, hydroxyl is introduced, hydroxyl is introduced into an ethanol solution of 3 - dodecyl triethoxysilane, hydroxyl is introduced, hydroxyl is introduced, and finally silanol cyanate is immersed in a dodecyl trimethyl diisocyanate ethanol solution to obtain the modified hexamethylene diisocyanate. M1, and finally, the silicon alcohol M1 cyanate ester is immersed in an aqueous solution to obtain the modified hexamethylene diisocyanate resin, and finally, the hydroxyl is introduced into an ethanol solution of M3 the dodecyl trimethyl diisocyanate to obtain the modified hexamethylenediisocyanate resin. (by machine translation)

SILANE COMPOSITIONS FOR POLYESTER NANOCOMPOSITES

Novel silane compositions have been prepared by reacting a 3-isocyanatopropyl trialkoxysilane with an alcohol or diol having a divalent alkylene or alkylene-ether group. The alcohol or diol has a formula weight less than about 5000. The compositions can be used to modify the surfaces of inorganic oxygen-containing materials, including but not limited to silica, silicates, borosilicates, aluminosilicates, days, and metal oxides. Surface treatment of silica nanoparticles with these compositions improves their improved dispersion in polyester nanocomposites.