75427-24-6Relevant academic research and scientific papers
Heterogeneous copper-catalyzed decarboxylative cyclization of 2-benzoylpyridines with α-amino acids leading to imidazo[1,5-a]pyridines
Liao, Yang,Yan, Chenyu,Zhang, Rongli,Cai, Mingzhong
, p. 1 - 12 (2018/12/11)
The heterogeneous decarboxylative cyclization reaction between 2-benzoylpyridines and α-amino acids was achieved in toluene at 120 °C in the presence of 15 mol% of L-proline-functionalized MCM-41-supported copper(II) complex [L-Proline-MCM-41-Cu(OTf)
Lewis Acid-Catalyzed Denitrogenative Transannulation of Pyridotriazoles with Nitriles: Synthesis of Imidazopyridines
Joshi, Abhisek,Mohan, Darapaneni Chandra,Adimurthy, Subbarayappa
, p. 9461 - 9469 (2016/10/18)
The synthesis of imidazo[1,5-a]pyridines through denitrogenative transannulation of pyridotriazoles with nitriles using BF3·Et2O as catalyst has been described. The combination of solvents (dichlorobenzene-dichloroethane) plays a crucial role in achieving quantitative yields of desired products under metal-free conditions.
Copper-catalyzed denitrogenative transannulation reaction of pyridotriazoles: Synthesis of imidazo[1,5-a]pyridines with amines and amino acids
Joshi, Abhisek,Chandra Mohan, Darapaneni,Adimurthy, Subbarayappa
supporting information, p. 464 - 467 (2016/02/18)
The copper-catalyzed aerobic oxidative synthesis of imidazo[1,5-a]pyridines via cascade denitrogenative transannulation reaction of pyridotriazoles with benzylamines with good functional group tolerance is developed. The present methodology is also applicable to amino acids to obtain imidazo[1,5-a]pyridines via decarboxylative oxidative cyclization.
Synthesis of 1,3-Disubstituted Imidazo[1,5-a]pyridines from Amino Acids via Catalytic Decarboxylative Intramolecular Cyclization
Wang, Huiqiao,Xu, Wentao,Xin, Lilan,Liu, Wenmin,Wang, Zhiqiang,Xu, Kun
, p. 3681 - 3687 (2016/05/24)
A copper/iodine cocatalyzed decarboxylative cyclization of α-amino acids is described. Starting from the readily available amino acids and either 2-benzoylpyridines or 2-benzoylquinolines, 1,3-disubstituted imidazo[1,5-a]pyridines and 1,3-disubstituted im
Approaches for the introduction of fluorinated substituents into [1,2,3]Triazolo[1,5-a]pyridines
Chiassai, Leonardo,Adam, Rosa,Drechslerová, Marcela,Ballesteros, Rafael,Abarca, Belén
, p. 44 - 50 (2014/07/07)
[1,2,3]Triazolo[1,5-a]pyridines functionalization with a trifluoromethyl group has been achieved for the first time using different synthetic strategies. Furthermore, these scaffolds have been employed as starting material in the synthesis of new 2,6-disubstituted pyridines containing the trifluoromethyl group, compounds that are not available using other methodologies. A fluorine-mediated triazolopyridine dimerisation is described, improving the previously known synthetic method. Preliminary studies focused on exploring triazolopyridines reactivity with electrophilic fluorine have revealed a new approach for the obtainment of imidazopyridines.
A one-pot synthesis of imidazo[1,5-a]pyridines
Crawforth, James M.,Paoletti, Melissa
experimental part, p. 4916 - 4918 (2009/12/01)
A one-pot synthesis of imidazo[1,5-a]pyridines starting from a carboxylic acid and 2-methylaminopyridines allowing introduction of various substituents at the 1- and 3-positions is achieved using propane phosphoric acid anhydride in ethyl or n-butyl aceta
The Nitration of Imidazopyridines
Glover, Edward E.,Peck, Leonard, W.
, p. 959 - 962 (2007/10/02)
Imidazopyridines in acetic acid solution are readily nitrated by nitric acid-sulphuric acid, although in some instances treatment of the base hydrogensulphate with nitric acid-acetic acid is preferred.Nitration occurs most readily in the 1-position, but 3-nitration occurs if the 1-position is already substituted.
