75532-94-4

Upstream product

• 6516-41-2 1-benzyl-3-(methoxycarbonyl)pyridinium bromide 
• 7146-29-4 1-benzyl-3-methoxycarbonyl-pyridinium; chloride 
• 126225-89-6 1-(2-bromobenzyl)-3-methoxycarbonyl-1,4,5,6-tetrahydropyridine 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 2905-56-8 N-Benzylpiperidine 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 

Downstream Products

• 288587-17-7 1-benzyl-2-(benzylamino-methyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 288587-15-5 1-Benzyl-2-[(E)-benzylimino-methyl]-pyrrolidine-2-carboxylic acid methyl ester 
• 288587-13-3 1-benzyl-2-formyl-pyrrolidine-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

C(sp3)-H dehydrogenation and C(sp2)-H alkoxy carbonylation of inactivated cyclic amines towards functionalized N-heterocycles

A novel and efficient synthesis of tetrahydropyridine (THP)-, dihydropyrrole (DHP)-, or tetrahydroazepine (THA)-3-carboxylates via cascade reactions of inactivated cyclic amines with CO and alcohols is presented. To our knowledge, this should be the first

Synthetic method of cyclic enamine-3-formic acid ester compound

The invention discloses a synthetic method of a cyclic enamine-3-formic acid ester compound and belongs to the field of organic synthesis technology. The main point of the technical scheme is as shown in the specification. In comparison with the prior art, the invention has the following advantages: (1) by the adoption of one-pot cascade reaction, tedious intermediate separation purification process is avoided, waste emission is decreased, and environmental burden is reduced; (2) raw materials are easily available; (3) the reaction is carried out at the temperature of minus 100 DEG C, condition is mild, and operation is simple; (4) the application range of a substrate is wide; and (5) atom economy of the reaction is high.

Pyrrolidines bearing a quaternary α-stereogenic center. Part 2: Access to proline chimeras, stereoselective approach and mechanistic aspects

The present work describes the access to various proline chimeras bearing a quaternary α-stereogenic center, via the Duhamel ring contraction of heterocyclic enamines. Attempts to induce diastereoselectivity are reported. The 'chiral enamine' strategy aff

The Synthesis of Indolizidine and Quinolizidine Ring Systems by Free Radical Cyclization of 4-Aza-6-methoxycarbonyl-5-hexenyl Radicals

The formation of bicyclic amines by the intramolecular cyclization of 4-aza-6-methoxycarbonyl-5-hexenyl radicals is described.The direct attachment of a nitrogen atom to the double bond changes the electronic nature of the alkene such that the cyclization is less efficient than the all carbon analogue or the other aza-substituted 5-hexenyl cyclizations.The reaction has been used in a short, convenient synthesis of a variety of indolizidines from methyl nicotinate.In addition, the cyclization was used as the key step in a short synthesis of (+/-)-epilupinine from methyl nicotinate.