75625-99-9

Usage

Uses

Used in Pharmaceutical Industry:
2-[4-(2-Methyl-propenyl)phenyl]propionic Acid is used as an intermediate in the synthesis of pharmaceutical compounds for its potential anti-inflammatory properties. Its structural similarity to Ibuprofen suggests that it may have related therapeutic effects, making it a valuable component in the development of new medications.
Used in Chemical Research:
As a byproduct of Ibuprofen synthesis, 2-[4-(2-Methyl-propenyl)phenyl]propionic Acid can be utilized in chemical research to explore its properties and potential applications. Researchers may investigate its reactivity, stability, and interactions with other molecules, which could lead to the discovery of new uses or improvements in existing processes.
Used in Analytical Chemistry:
2-[4-(2-Methyl-propenyl)phenyl]propionic Acid can be employed as a reference compound in analytical chemistry for the development and validation of analytical methods. Its unique structure and properties may be useful for testing and optimizing techniques such as chromatography, mass spectrometry, and spectrophotometry.

InChI:InChI=1/C13H16O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-8,10H,1-3H3,(H,14,15)

Upstream product

• 3017-69-4 2-methyl-1-propenylbromide 
• 34645-72-2 (RS)-2-(4'-iodophenyl)propanoic acid 
• 75625-98-8 2-propionic acid 
• 77601-60-6 ethyl 2-<(4-(2-methyl-1-propenyl)phenyl)>propionate 
• 859828-48-1 methyl 2-{4-(trifluoromethanesulfonyloxy)phenyl}propanoate 
• 10400-18-7 1-(4'-chlorophenyl)-2-methyl-1-propanol 
• 19366-15-5 4-chloro-β,β-dimethylstyrene 
• 51833-36-4 4-chlorophenylmagnesium chloride 
• 15687-27-1 ibuprofen 
• 126689-00-7 2-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-propene 
• 492-37-5 hydratropic acid 
• 915315-39-8 4-(2-methyl-1-propen-1-yl)phenylacetic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 75626-00-5 2-propionic acid 
• 15687-27-1 ibuprofen 
• 75626-01-6 2-propenoic acid 
• 51146-55-5 2-Hydroxyibuprofen 

Relevant academic research and scientific papers

Catalytic α-Deracemization of Ketones Enabled by Photoredox Deprotonation and Enantioselective Protonation

This study reports the catalytic deracemization of ketones bearing stereocenters in the α-position in a single reaction via deprotonation, followed by enantioselective protonation. The principle of microscopic reversibility, which has previously rendered this strategy elusive, is overcome by a photoredox deprotonation through single electron transfer and subsequent hydrogen atom transfer (HAT). Specifically, the irradiation of racemic pyridylketones in the presence of a single photocatalyst and a tertiary amine provides nonracemic carbonyl compounds with up to 97% enantiomeric excess. The photocatalyst harvests the visible light, induces the redox process, and is responsible for the asymmetric induction, while the amine serves as a single electron donor, HAT reagent, and proton source. This conceptually simple light-driven strategy of coupling a photoredox deprotonation with a stereocontrolled protonation, in conjunction with an enrichment process, serves as a blueprint for other deracemizations of ubiquitous carbonyl compounds.

para-Selective arylation and alkenylation of monosubstituted arenes using thianthreneS-oxide as a transient mediator

Using thianthreneS-oxide (TTSO) as a transient mediator,para-arylation and alkenylation of mono-substituted arenes have been demonstratedviaapara-selective thianthrenation/Pd-catalyzed thio-Suzuki-Miyaura coupling sequence under mild conditions. This reaction features a broad substrate scope, and functional group and heterocycle tolerance. The versatility of this approach was further demonstrated by late-stage functionalization of complex bioactive scaffolds, and direct synthesis of some pharmaceuticals, including Tetriprofen, Ibuprofen, Bifonazole, and LJ570.

Preparation method of para-substituted aryl compound

The invention discloses a preparation method of a para-substituted aryl compound shown as a formula (I) which is described in the specfication. The preparation method is characterized by comprising the following step of: subjecting an aryl sulfonium salt shown as a formula (II) which is described in the specfication and boride to a coupling reaction in a solvent in an inert atmosphere under the action of alkali and a palladium catalyst to obtain the para-substituted aryl compound. According to the method, mono-substituted aromatic hydrocarbon is taken as a substrate, the aryl sulfonium salt isconstructed in situ, and the palladium catalyst catalyzes the aryl sulfonium salt constructed in situ to undergo the Suzuki-Miyaura coupling reaction, so a mono-substituted aromatic hydrocarbon para-arylation or alkenylation product is constructed quickly and efficiently. The method is mild in conditions, high in substrate universality and wide in tolerance of a heterocyclic coupling substrate.

Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2

Chemokines CXCL8 and CXCL1 play a key role in the recruitment of neutrophils at the site of inflammation. CXCL8 binds two membrane receptors, CXCR1 and CXCR2, whereas CXCL1 is a selective agonist for CXCR2. In the past decade, the physiopathological role of CXCL8 and CXCL1 has been investigated. A novel class of small molecular weight allosteric CXCR1 inhibitors was identified, and reparixin, the first drug candidate, is currently under clinical investigation in the prevention of ischemia/reperfusion injury in organ transplantation. Reparixin binding mode to CXCR1 has been studied and used for a computer-assisted design program of dual allosteric CXCR1 and CXCR2 inhibitors. In this paper, the results of modeling-driven SAR studies for the identification of potent dual inhibitors are discussed, and three new compounds (56, 67, and 79) sharing a common triflate moiety have been selected as potential leads with optimized pharmacokinetic characteristics.

Synthesis of Arylpropanoic Acids From Optically Active 2-(Iodophenyl)propanoic Acids

The coupling of organozinc compounds with homochiral 2-(3-iodophenyl)propanoic and 2-(4-iodophenyl)propanoic acids in the presence of palladium is a general method for the synthesis of optically active arylpropanoic acids.