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75822-13-8

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75822-13-8 Usage

General Description

1-(4-(dimethylamino)phenyl)-2,2,2-trifluoroethanol is a chemical compound with the molecular formula C10H12F3NO. It is a substituted phenol derivative, containing a trifluoromethyl group and a dimethylamino group. 1-(4-(diMethylaMino)phenyl)-2,2,2-trifluoroethanol is commonly used as a reagent in organic synthesis, especially in the preparation of various pharmaceuticals. It has been studied for its potential as a chiral auxiliary in asymmetric synthesis and as a precursor for the synthesis of novel fluorinated compounds. The trifluoroethanol moiety in the compound also imparts unique physicochemical properties, making it useful as a solvent in various chemical reactions and as a stabilizer for proteins and peptides. Additionally, it has potential applications in the field of materials science and in medicinal chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 75822-13-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,8,2 and 2 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 75822-13:
(7*7)+(6*5)+(5*8)+(4*2)+(3*2)+(2*1)+(1*3)=138
138 % 10 = 8
So 75822-13-8 is a valid CAS Registry Number.

75822-13-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[4-(dimethylamino)phenyl]-2,2,2-trifluoroethanol

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:75822-13-8 SDS

75822-13-8Downstream Products

75822-13-8Relevant articles and documents

Asymmetric Hydrogenation of Aryl Perfluoroalkyl Ketones Catalyzed by Rhodium(III) Monohydride Complexes Bearing Josiphos Ligands

Brüning, Fabian,Nagae, Haruki,K?ch, Daniel,Mashima, Kazushi,Togni, Antonio

supporting information, p. 10818 - 10822 (2019/07/31)

The asymmetric hydrogenation of 2,2,2-trifluoroacetophenones and aryl perfluoroalkyl ketones was developed using a unique, well-defined chloride-bridged dinuclear rhodium(III) complex bearing Josiphos-type diphosphine ligands. These complexes were prepared from [RhCl(cod)]2, Josiphos ligands, and hydrochloric acid. As catalyst precursors, they allow for the efficient and enantioselective synthesis (up to 99 % ee) of chiral secondary alcohols with perfluoroalkyl groups. This system does not require an activating base for the hydrogenation of 2,2,2-trifluoroacetophenones. Additionally, the enantioselective C=O hydrogenations of 2-phenyl-3-(haloacetyl)-indoles, a class of privileged structures in medicinal chemistry, is reported for the first time.

Trifluoromethylation of ketones and aldehydes with Bu3SnCF 3

Sanhueza, Italo A.,Bonney, Karl J.,Nielsen, Mads C.,Schoenebeck, Franziska

, p. 7749 - 7753 (2013/09/02)

The (trifluoromethyl)stannane reagent, Bu3SnCF3, was found to react under CsF activation with ketones and aldehydes to the corresponding trifluoromethylated stannane ether intermediates at room temperature in high yield. Only a mildly acidic extraction (aqueous NH 4Cl) is required to release the corresponding trifluoromethyl alcohol products. The protocol is compatible with acid-sensitive functional groups.

Amidinate salt of hexafluoroacetone hydrate for the preparation of fluorinated compounds by the release of trifluoroacetate

Riofski, Mark V.,Hart, Allison D.,Colby, David A.

supporting information, p. 208 - 211 (2013/04/10)

A powerful, new reagent, an amidinate salt of hexafluoroacetone hydrate, is an air-stable salt that can be used for the preparation of fluorinated organic molecules. Nucleophilic trifluoromethylation reactions are demonstrated following the base-promoted release of trifluoroacetate. This reagent is soluble in many polar organic solvents and produces fluoroform, following the release of trifluoroacetate. Reactions with this reagent and common electrophiles provide excellent yields of trifluoromethylated products.

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