76107-49-8Relevant academic research and scientific papers
PEGYLATED OPIOID WITH LOW ADDICTIVE EFFECT
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Paragraph 0062; 0066, (2018/12/13)
Provided in the present invention are a conjugate of polyethylene glycol and opioid as shown in general formula (I), and a pharmaceutical composition comprising the conjugate. By means of covalently bonding a plurality of opioids to a polyethylene glycol derivative, the present invention improves water solubility and pharmacokinetic property of the drug with a low addictive effect. ????????PEG-(X-OP)m?????(I)
Structure and receptor interactions of morphinomimetics. Part I. Hydroxy and methoxy derivatives of fentanyl and some morphine analogues
Lobbezoo,Soudijn,Van Wijngaarden
, p. 357 - 361 (2007/10/02)
The opiate receptor affinity of a number of fentanyl derivatives was determined by in vitro receptor binding studies and compared with that of morphine-like structures. The phenolic OH groups in morphine and in a benzomorphan derivative have a strong affi
