76107-52-3Relevant academic research and scientific papers
PEGYLATED OPIOID WITH LOW ADDICTIVE EFFECT
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Paragraph 0062; 0067, (2018/12/13)
Provided in the present invention are a conjugate of polyethylene glycol and opioid as shown in general formula (I), and a pharmaceutical composition comprising the conjugate. By means of covalently bonding a plurality of opioids to a polyethylene glycol derivative, the present invention improves water solubility and pharmacokinetic property of the drug with a low addictive effect. ????????PEG-(X-OP)m?????(I)
COMPOSITIONS, DOSAGE FORMS, AND COADMINISTRATION OF AN OPIOID AGONIST COMPOUND AND AN ANALGESIC COMPOUND
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Paragraph 00254, (2013/05/23)
The present invention relates generally to the co-administration of an opioid agonist compound and an analgesic compound. In addition, the invention relates to, among other things, dosage forms for co-administration of an opioid agonist compound and an analgesic compound, methods for administering an opioid agonist compound and an analgesic compound, compositions comprising an opioid agonist compound and an analgesic compound, dosage forms comprising an opioid agonist compound and an analgesic compound, and so on.
Structure and receptor interactions of morphinomimetics. Part I. Hydroxy and methoxy derivatives of fentanyl and some morphine analogues
Lobbezoo,Soudijn,Van Wijngaarden
, p. 357 - 361 (2007/10/02)
The opiate receptor affinity of a number of fentanyl derivatives was determined by in vitro receptor binding studies and compared with that of morphine-like structures. The phenolic OH groups in morphine and in a benzomorphan derivative have a strong affi
