761449-63-2Relevant academic research and scientific papers
PROCESS FOR PREPARATION OF S-(-)-BETAXOLOL AND SALTS THEREOF
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Page/Page column 2-5, (2010/02/15)
The present invention relates to an improved process for preparation of S-(?)-betaxolol salts. More particularly the present invention relates to the preparation of hydrochloride salt of S-(?)-betaxolol of formula (1).
A convenient synthesis of the enantiomerically pure β-blocker (S)-betaxolol using hydrolytic kinetic resolution
Joshi, Ramesh A.,Garud, Dinesh R.,Muthukrishnan,Joshi, Rohini R.,Gurjar
, p. 3802 - 3806 (2007/10/03)
Enantiopure (S)-betaxolol was prepared in an extremely simple and practical way using hydrolytic kinetic resolution of a terminal epoxide by Jacobsen's catalyst. High enantiomeric purity (99% ee) has been achieved and the method is amenable to industrial scale-up.
