7617-76-7

Basic information

• Product Name: 3-PHENOXY-PROPYLAMINE
• Synonyms: CHEMBRDG-BB 4018151;AKOS BC-0465;3-PHENOXYPROPAN-1-AMINE;3-PHENOXY-PROPYLAMINE;RARECHEM AL BW 2165;p80255;(3-phenoxypropyl)amine(SALTDATA: HCl);(3-phenoxypropyl)amine 1HCl
• CAS NO: 7617-76-7
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.21
• Mol File: 7617-76-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 253.9°C at 760 mmHg
• Flash Point: 110.3°C
• Appearance: /
• Density: 1.007g/cm³
• Vapor Pressure: 0.0178mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: 3-PHENOXY-PROPYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENOXY-PROPYLAMINE(7617-76-7)
• EPA Substance Registry System: 3-PHENOXY-PROPYLAMINE(7617-76-7)

Safety Data

• Hazardous Substances Data: 7617-76-7(Hazardous Substances Data)

Usage

General Description

3-Phenoxy-propylamine is a chemical compound primarily used in the synthesis of pharmaceuticals and other organic compounds. It falls under the category of alkylamines and aromatic amines. 3-PHENOXY-PROPYLAMINE consists of a propylamine chain attached to a phenoxy group, and its derivatives are often used in the development of various drugs. It is also used as a reagent in chemical reactions due to its ability to donate electrons. It is generally found in liquid form at room temperature and must be handled with appropriate safety measures due to its potential to cause skin and eye irritation.

InChI:InChI=1/C9H13NO/c10-7-4-8-11-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8,10H2

Upstream product

• 104053-83-0 N-3-phenoxypropylacetamide 
• 60-29-7 diethyl ether 
• 3055-86-5 3-phenoxypropionitrile 
• 7647-01-0 hydrogenchloride 
• 6180-61-6 3-phenoxypropanol 
• 591-50-4 iodobenzene 
• 156-87-6 propan-1-ol-3-amine 
• 139-02-6 sodium phenoxide 
• 108-95-2 phenol 
• 588-63-6 3-phenoxypropyl bromide 
• 104053-84-1 N-3-phenoxypropylpropionamide 
• 83708-38-7 (3-phthalimidopropyl)-phenyl ether 

Downstream Products

• 101867-50-9 3,3'-(3-phenoxy-propylimino)-di-propionic acid dimethyl ester 
• 857582-24-2 N-[5-(3-phenoxy-propylamino)-pentyl]-benzamide 
• 107539-65-1 7-[(1R,2R)-2-(3-Phenoxy-propylamino)-cyclopentyl]-heptanoic acid ethyl ester 
• 107539-65-1 7-[(1S,2R)-2-(3-Phenoxy-propylamino)-cyclopentyl]-heptanoic acid ethyl ester 
• 103524-35-2 2-Isopropyl-5-(3-phenoxy-propylamino)-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile 
• 98510-48-6 2-amino-5-nitroso-6-(3-phenoxypropyl)aminopyrimidin-4(3H)-one 
• 71259-64-8 (7-chloro-1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-(3-phenoxy-propyl)-amine 

Relevant articles and documents

Aqueous olefin hydroformylation using water-soluble mono- and trinuclear N,O-chelate rhodium(I)-aryl ether precatalysts

Water-soluble, sulfonated, salicylaldiminato-aryl ether mono- (7) and trimeric (8) ligands were prepared and reacted with the [Rh(μ-Cl)(η2:η2?COD)]2 dimer to yield the corresponding water-soluble mononuclear (9) and trinuc

Direct Primary Amination of Alkylmetals with NH-Oxaziridine

A method for the primary electrophilic amination of primary, secondary, and tertiary organometallic substrates from a bench-stable NH-oxaziridine reagent is described. This facile and highly chemoselective transformation occurs at ambient temperature and without transition metal catalysts or purification by column chromatography to provide alkylamine products in a single step. Density functional theory (DFT) calculations revealed that, despite the basicity of alkylmetals, the direct NH-transfer pathway is favored over proton and O-transfer.

Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation

A series of 9-N-substituted berberine derivatives were synthesized and biologically evaluated as antioxidant and inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase and amyloid-β aggregation. Most of these compounds exhibited very good antioxidant activities, inhibitive activities of AChE and amyloid-β aggregation. Among them, compound 8d, (o-methylphenethyl)amino linked at the 9-position of berberine, was found to be a good antioxidant (with 4.05 μM of Trolox equivalents), potent inhibitor of AChE (an IC50 value of 0.027 μM), and high active inhibitor of amyloid-β aggregation (an IC50 value of 2.73 μM).