104053-83-0

Basic information

• Product Name: N-3-phenoxypropylacetamide
• Synonyms: N-3-phenoxypropylacetamide
• CAS NO: 104053-83-0
• Molecular Weight: 193.246
• Mol File: 104053-83-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-3-phenoxypropylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-3-phenoxypropylacetamide(104053-83-0)
• EPA Substance Registry System: N-3-phenoxypropylacetamide(104053-83-0)

Safety Data

• Hazardous Substances Data: 104053-83-0(Hazardous Substances Data)

Upstream product

• 75-36-5 acetyl chloride 
• 7617-76-7 3-phenoxypropanamine 

Downstream Products

• 160408-06-0 ethyl-(3-phenoxy-propyl)-amine 
• 64-19-7 acetic acid 
• 156-87-6 propan-1-ol-3-amine 
• 7617-76-7 3-phenoxypropanamine 
• 108-95-2 phenol 

Relevant articles and documents

Synthesis of potent non-imidazole histamine H3-receptor antagonists

Histamine has been converted into a non-imidazole H3-receptor histamine antagonist by addition of a 4-phenylbutyl group at the N(α)-position followed by removal of the imidazole ring. The resulting compound, N-ethyl- N-(4-phenylbutyl)amine, remarkably has a Ki = 1.3 μM as an H3 antagonist. Using this as a lead compound, a novel series of homologous O and S isosteric tertiary amines was synthesised and structure-activity studies furnished N- (5-phenoxypentyl)pyrrolidine (Ki = 0.18 ± 0.10 μM, for [3H]histamine release from rat cerebral cortex synaptosomes) which, more importantly, was active in vivo. Substitution of NO2 into the para position of the phenoxy group gave N-(5-p-nitrophenoxypentyl)pyrrolidine, UCL 1972 (Ki= 39 ± 11 nM), ED50 = 1.1 ± 0.6 mg/kg per os in mice on brain tele-methylhistamine levels.