76526-43-7

Basic information

• Product Name: methyl 3,3-dimethoxy-2-methylpropionate
• Synonyms: methyl 3,3-dimethoxy-2-methylpropionate;2-Methyl-3,3-dimethoxypropionic acid methyl ester;3,3-Dimethoxy-2-methylpropanoic acid methyl ester;3,3-dimethoxy-2-methyl-propionic acid methyl ester;Propanoic acid,3,3-dimethoxy-2-methyl-, methyl ester
• CAS NO: 76526-43-7
• Molecular Formula: C₇H₁₄O₄
• Molecular Weight: 162.18366
• EINECS: 278-485-5
• Mol File: 76526-43-7.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 192.7°C at 760 mmHg
• Flash Point: 72.1°C
• Appearance: /
• Density: 1.007g/cm³
• Vapor Pressure: 0.482mmHg at 25°C
• Refractive Index: 1.407
• CAS DataBase Reference: methyl 3,3-dimethoxy-2-methylpropionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3,3-dimethoxy-2-methylpropionate(76526-43-7)
• EPA Substance Registry System: methyl 3,3-dimethoxy-2-methylpropionate(76526-43-7)

Safety Data

• Hazardous Substances Data: 76526-43-7(Hazardous Substances Data)

Usage

General Description

Methyl 3,3-dimethoxy-2-methylpropionate is a chemical compound with the molecular formula C8H16O4. It belongs to the ester group of organic compounds and is commonly used as a flavoring agent, fragrance ingredient, and solvent in various industries. It is a clear, colorless liquid with a fruity, slightly floral odor. This chemical is also used as a key intermediate in the synthesis of other compounds and is often employed in the production of pharmaceuticals, agrochemicals, and other fine chemicals due to its versatile reactivity and compatibility with a wide range of other chemicals. Additionally, it serves as a solvent in various coating formulations and is known for its low toxicity and high stability, making it a favorable choice for industrial applications.

InChI:InChI=1/C7H14O4/c1-5(6(8)9-2)7(10-3)11-4/h5,7H,1-4H3

Upstream product

• 5445-17-0 Methyl 2-bromopropionate 
• 149-73-5 trimethyl orthoformate 
• 3673-79-8 methyl 2,3-dibromoisobutyrate 
• 80-62-6 methacrylic acid methyl ester 
• 124-41-4 sodium methylate 
• 98014-00-7 3-(Acetyl-cyclohexyl-amino)-2-methyl-propionic acid methyl ester 
• 67-56-1 methanol 
• 86934-31-8 bis(1-methoxy-1-propenyloxy)dimethylsilane 
• 98014-03-0 3-(Acetyl-cyclohexyl-amino)-3-methoxy-2-methyl-propionic acid methyl ester 

Downstream Products

• 27287-73-6 2‐amino‐6‐methyl‐4H‐[1,2,4]triazolo[1,5‐a]pyrimidin‐5‐one 
• 82387-42-6 Methyl 3-methoxy-2-methyl-2-propenoate 
• 919608-38-1 3-{3-benzyloxy-4-(5-methyl-tetrahydro-furan-2-yl)-1-[2-(toluene-4-sulfonyloxy)-ethyl]-pentyloxy}-2-methyl-acrylic acid methyl ester 
• 867061-53-8 (E)-3-{(1R,3R)-3-Benzyloxy-1-[2-(toluene-4-sulfonyloxy)-ethyl]-pentyloxy}-2-methyl-acrylic acid methyl ester 
• 849482-34-4 (E)-3-{(1R,3S)-3-Benzyloxy-1-[2-(toluene-4-sulfonyloxy)-ethyl]-butoxy}-2-methyl-acrylic acid methyl ester 
• 482626-53-9 C₄₄H₅₀O₁₁S 
• 51673-64-4 methyl 2-methyl-3-oxopropanoate 

Relevant articles and documents

A preparation method of the emetic (by machine translation)

The invention relates to the field of organic synthetic technology, in particular to a emetic preparation method, comprises the following steps: S1, 3 - methoxy methyl acrylic acid methyl ester preparation; S2, synthesis of [...]; S3, is the synthesis of third zuo; S4, and aldehyde; S5, closed-loop. This invention adopts the single melamine as the synthetic starting material, greatly reducing the cost, dicyandiamide as to effectively solve the problem of lack of raw material sources; solved in the prior art long reaction time, the reaction condition is sensitive, harsh, side reaction are numerous and complex, the use of expensive or difficult to prepare sodium of other reagents, reactions caused low overall yield, the product quality is poor, so that the synthesis process technology of the route is more stable, good reproducibility, high yield, the product quality is good, content can be up to 99.5%, the yield can reach 85.6%, has higher economic benefits. (by machine translation)

Discovery of a novel series of pyrazolo[1,5-a]pyrimidine-based phosphodiesterase 2A inhibitors structurally different from N-((1S)-1-(3-fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the treatment of cognitive disorders

It has been hypothesized that selective inhibition of phosphodiesterase (PDE) 2A could potentially be a novel approach to treat cognitive impairment in neuropsychiatric and neurodegenerative disorders through augmentation of cyclic nucleotide signaling pathways in brain regions associated with learning and memory. Following our earlier work, this article describes a drug design strategy for a new series of lead compounds structurally distinct from our clinical candidate 2 (TAK-915), and subsequent medicinal chemistry efforts to optimize potency, selectivity over other PDE families, and other preclinical properties including in vitro phototoxicity and in vivo rat plasma clearance. These efforts resulted in the discovery of N-((1S)-2-hydroxy-2-methyl-1-(4-(trifluoromethoxy)phenyl)propyl)-6-methyl-5-(3-methyl-1H-1,2,4triazol-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (20), which robustly increased 3′,5′-cyclic guanosine monophosphate (cGMP) levels in the rat brain following an oral dose, and moreover, attenuated MK-801-induced episodic memory deficits in a passive avoidance task in rats. These data provide further support to the potential therapeutic utility of PDE2A inhibitors in enhancing cognitive performance.

HETEROCYCLIC COMPOUND

A compound represented by the formula (I): wherein each symbol is as described in the SPECIFICATION, or a salt thereof has a PDE2A inhibitory action, and is useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like.