76526-43-7

Usage

Uses

Used in Flavor and Fragrance Industry:
Methyl 3,3-dimethoxy-2-methylpropionate is used as a flavoring agent and fragrance ingredient due to its distinctive fruity and slightly floral scent. Its ability to impart pleasant aromas makes it a valuable component in the creation of various fragrances and flavorings for consumer products.
Used in Solvent Applications:
This chemical compound serves as an effective solvent in various industries. Its solubility properties and low toxicity contribute to its use in dissolving and mixing with other chemicals, making it a preferred choice for a range of solvent-based applications.
Used in Pharmaceutical Production:
Methyl 3,3-dimethoxy-2-methylpropionate is utilized as a key intermediate in the synthesis of pharmaceuticals. Its versatile reactivity and compatibility with a broad spectrum of chemicals facilitate its use in the development and manufacturing of various medications.
Used in Agrochemical Synthesis:
In the agrochemical industry, methyl 3,3-dimethoxy-2-methylpropionate plays a crucial role as an intermediate in the synthesis of different agrochemicals. Its ability to react with a wide range of chemicals makes it instrumental in formulating effective agricultural products.
Used in Coating Formulations:
Methyl 3,3-dimethoxy-2-methylpropionate is employed as a solvent in various coating formulations. Its stability and low toxicity make it an advantageous component in the production of coatings that require a high level of performance and safety.

InChI:InChI=1/C7H14O4/c1-5(6(8)9-2)7(10-3)11-4/h5,7H,1-4H3

Upstream product

• 86934-31-8 bis(1-methoxy-1-propenyloxy)dimethylsilane 
• 149-73-5 trimethyl orthoformate 
• 3673-79-8 methyl 2,3-dibromoisobutyrate 
• 124-41-4 sodium methylate 
• 80-62-6 methacrylic acid methyl ester 
• 67-56-1 methanol 
• 5445-17-0 Methyl 2-bromopropionate 
• 98014-00-7 3-(Acetyl-cyclohexyl-amino)-2-methyl-propionic acid methyl ester 
• 98014-03-0 3-(Acetyl-cyclohexyl-amino)-3-methoxy-2-methyl-propionic acid methyl ester 

Downstream Products

• 51673-64-4 methyl 2-methyl-3-oxopropanoate 
• 867061-53-8 (E)-3-{(1R,3R)-3-Benzyloxy-1-[2-(toluene-4-sulfonyloxy)-ethyl]-pentyloxy}-2-methyl-acrylic acid methyl ester 
• 482626-53-9 C₄₄H₅₀O₁₁S 
• 919608-38-1 3-{3-benzyloxy-4-(5-methyl-tetrahydro-furan-2-yl)-1-[2-(toluene-4-sulfonyloxy)-ethyl]-pentyloxy}-2-methyl-acrylic acid methyl ester 
• 82387-42-6 Methyl 3-methoxy-2-methyl-2-propenoate 
• 27287-73-6 2‐amino‐6‐methyl‐4H‐[1,2,4]triazolo[1,5‐a]pyrimidin‐5‐one 
• 849482-34-4 (E)-3-{(1R,3S)-3-Benzyloxy-1-[2-(toluene-4-sulfonyloxy)-ethyl]-butoxy}-2-methyl-acrylic acid methyl ester 

Relevant academic research and scientific papers

A paraquat emetic and preparation method

The invention relates to the field of organic synthetic technology, in particular to a paraquat emetic and preparation method, comprises the following preparation steps, S1, preparation of [...]; S2, the preparation of the etherification; S3, pyrimidine triazole; S4, PP796 preparation. The invention one-pot method for directly simple high yield of synthetic method is more suitable for industrial production technology, the process route and is simple, low cost, production and operation method is simple and convenient, high yield, the total yield to methacrylic acid methyl ester idea can reach 43.5% or more, the obtained product and luster is pure white, crystalline state is good, content ≥ 99%.

A preparation method of the emetic (by machine translation)

The invention relates to the field of organic synthetic technology, in particular to a emetic preparation method, comprises the following steps: S1, 3 - methoxy methyl acrylic acid methyl ester preparation; S2, synthesis of [...]; S3, is the synthesis of third zuo; S4, and aldehyde; S5, closed-loop. This invention adopts the single melamine as the synthetic starting material, greatly reducing the cost, dicyandiamide as to effectively solve the problem of lack of raw material sources; solved in the prior art long reaction time, the reaction condition is sensitive, harsh, side reaction are numerous and complex, the use of expensive or difficult to prepare sodium of other reagents, reactions caused low overall yield, the product quality is poor, so that the synthesis process technology of the route is more stable, good reproducibility, high yield, the product quality is good, content can be up to 99.5%, the yield can reach 85.6%, has higher economic benefits. (by machine translation)

Discovery of a novel series of pyrazolo[1,5-a]pyrimidine-based phosphodiesterase 2A inhibitors structurally different from N-((1S)-1-(3-fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the treatment of cognitive disorders

It has been hypothesized that selective inhibition of phosphodiesterase (PDE) 2A could potentially be a novel approach to treat cognitive impairment in neuropsychiatric and neurodegenerative disorders through augmentation of cyclic nucleotide signaling pathways in brain regions associated with learning and memory. Following our earlier work, this article describes a drug design strategy for a new series of lead compounds structurally distinct from our clinical candidate 2 (TAK-915), and subsequent medicinal chemistry efforts to optimize potency, selectivity over other PDE families, and other preclinical properties including in vitro phototoxicity and in vivo rat plasma clearance. These efforts resulted in the discovery of N-((1S)-2-hydroxy-2-methyl-1-(4-(trifluoromethoxy)phenyl)propyl)-6-methyl-5-(3-methyl-1H-1,2,4triazol-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (20), which robustly increased 3′,5′-cyclic guanosine monophosphate (cGMP) levels in the rat brain following an oral dose, and moreover, attenuated MK-801-induced episodic memory deficits in a passive avoidance task in rats. These data provide further support to the potential therapeutic utility of PDE2A inhibitors in enhancing cognitive performance.

HETEROCYCLIC COMPOUND

A compound represented by the formula (I): wherein each symbol is as described in the SPECIFICATION, or a salt thereof has a PDE2A inhibitory action, and is useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like.

Heterocyclic compound

A compound represented by the formula (I): wherein each symbol is as described in the SPECIFICATION, or a salt thereof has a PDE2A inhibitory action, and is useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer’s disease and the like.

2-ARYLTHIAZOLE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS

The invention encompasses compounds of Formula I or pharmaceutically acceptable salts thereof, which are modulators of the CXCR3 chemokine receptor function useful for the treatment or prevention of pathogenic inflammatory processes, autoimmune diseases or graft rejection processes. Methods of use and pharmaceutical compositions are also encompassed.

SuperQuat 5,5-dimethyl-4-iso-propyloxazolidin-2-one as a mimic of Evans 4-tert-butyloxazolidin-2-one

The incorporation of a gem-dimethyl group at the 5-position of a chiral oxazolidinone biases the conformation of the adjacent C(4)-stereodirecting group such that the gem-dimethyl-4-iso-propyl combination mimics a C(4)-tert-butyl group, providing higher levels of stereocontrol than a simple 4-iso-propyloxazolidinone. The generality of this principle is demonstrated with applications in stereoselective enolate alkylations, kinetic resolutions, Diels-Alder cycloadditions and Pd-catalysed asymmetric acetalisation reactions. The Royal Society of Chemistry 2006.

Process for preparing beta-L-2'deoxy-thymidine

The present invention relates to a new, essentially four-step process for preparing beta-L-2′-deoxy-thymidine starting from L-arabinose. The process according to the invention is particularly important for mass production of beta-L-2′-deoxy-thymidine.

Stereoselective synthesis of pamamycin-607

A macrodiolide antibiotic pamamycin-607 was synthesized by joining two hydroxy acid components. Three cis-2, 5-disubstituted tetrahydrofuran rings in the molecule were stereoselectively prepared by radical cyclization reactions of β-alkoxyvinyl ketone intermediates and a β-alkoxymethacrylate substrate. The key step of the synthesis is characterized by the predominant threo product formation in the radical cyclization reaction of a β-alkoxymethacrylate intermediate.

HSAB driven chemoselectivity in alkylation of uracil derivatives. A high yielding preparation of 3-alkylated and unsymmetrically 1,3-dialkylated uracils

A qualitative hardness scale (N134) has been found for the conjugated bases of 2-methoxy-4(3H)-pyrimidinones 1-3 and applied to high yielding chemoselective N3 methylation, ethylation and benzylation reactions. Removal of the 2-methoxy group followed by a second alkylation affords unsymmetrically 1,3-disubstituted uracils.