76698-68-5Relevant articles and documents
A facile lipase-catalyzed KR approach toward enantiomerically enriched homopropargyl alcohols
Borowiecki, Pawe?,Dranka, Maciej
supporting information, (2019/02/14)
Compounds possessing propargylic (prop-2-ynylic) system are very important building blocks for organic chemistry. Among them, preparation of enantiomeric homopropargyl alcohols (but-3-yn-1-ols) constitutes a key-challenge for asymmetric synthesis and thus
Iterative synthesis of oligo-1,4-diols via catalytic anti-Markovnikov hydration of terminal alkynes
Kribber, Thomas,Labonne, Aurelie,Hintermann, Lukas
, p. 2809 - 2818 (2008/03/14)
A sequential, iterative synthesis of oligo-1,4-diol building blocks has been realized via (a) propargylation of an aldehyde with allenylzinc bromide, (b) alcohol protection and (c) ruthenium-catalyzed anti-Markovnikov hydration of the terminal alkyne to r
On the Use of 3-Bromopropyne as a Reagent for the Introduction of the Pyruvate Moiety
Chen, Chen,Crich, David
, p. 1289 - 1290 (2007/10/02)
In the presence of metallic zinc 3-bromopropyne reacts with aldehydes to give homopropynylic alcohols which are converted to the corresponding bromohomopropynylic acetates by acetylation followed by reaction with N-bromosuccinimide and a catalytic quantity of silver acetate; these derivatives are then oxidized to γ-acetoxy-α-ketoesters with osmium tetroxide and tert-butyl hydroperoxide resulting in a convenient four step sequence for the introduction of the pyruvate moiety.
