7702-09-2Relevant articles and documents
Preparation method for 2-diazonium-1-alkyl ketone compound
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Paragraph 0054; 0055; 0056; 0057; 0058, (2017/06/02)
The invention provides a preparation method for a 2-diazonium-1-alkyl ketone compound. The preparation method is characterized in that a beta-dicarbonyl compound, p-toluenesulfonyl azide and methylamine are taken as raw materials, and a catalyst and alkali are not needed under a room-temperature condition, so that the 2-diazonium-1-alkyl ketone compound can be quickly and efficiently generated. Compared with the prior art, the preparation method is safe, simple and convenient to operate, and avoids a diazotization step which is dangerous to operate. The preparation method is gentle in reaction condition, is quick and efficient, and provides a brand-new and more convenient method for quickly and efficiently preparing an alpha-diazonium-alkyl ketone compound, and the method can be applied to the fields such as the chemical pharmaceuticals, the biological field and the material field.
Tandem Synthesis of α-Diazoketones from 1,3-Diketones
Zhang, Jianlan,Chen, Wenwen,Huang, Dayun,Zeng, Xiaobao,Wang, Xinyan,Hu, Yuefei
, p. 9171 - 9174 (2017/09/11)
A highly efficient synthesis of α-diazoketone was achieved by simply stirring the mixture of 1,3-diketone, TsN3, and MeNH2 in EtOH. It was a tandem reaction including a novel primary amine-catalyzed Regitz diazo transfer of 1,3-diket
An efficient PEG-400 mediated catalyst free green synthesis of 2-amino-thiazoles from α-diazoketones and thiourea
Babu, B Hari,Vijay,Murali Krishna, K Bala,Sharmila,Ramana, M Baby
, p. 1475 - 1478 (2016/09/19)
A simple and efficient method has been developed for the synthesis of 2-aminothiazoles from α-diazoketones using PEG-400 solvent system. This novel synthetic approach involves the reaction between thiourea and α-diazoketones in PEG-400 at 100 °C to yield the corresponding 2-aminothiazoles in good yields. The method is simple, rapid and generates thiazole derivatives in excellent yields without the use of any catalysts. This green protocol can be utilized for fast synthesis of various 2-aminothiazoles in good yields. [Figure not available: see fulltext.]
Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor
Martin, Laetitia J.,Marzinzik, Andreas L.,Ley, Steven V.,Baxendale, Ian R.
supporting information; experimental part, p. 320 - 323 (2011/03/23)
A flow method for the synthesis of aliphatic and aromatic diazoketones from acyl chloride precursors has been developed and used to prepare quinoxalines in a multistep sequence without isolation of the potentially explosive diazoketone. The protocol showcases an efficient in-line purification using supported scavengers with time-saving and safety benefits and in particular a reduction in the operator's exposure to carcinogenic phenylenediamines.
First example of the coupling of α-diazoketones with thiourea: a novel route for the synthesis of 2-aminothiazoles
Yadav,Reddy, B.V. Subba,Rao, Y. Gopala,Narsaiah
, p. 2381 - 2383 (2008/09/18)
α-Diazoketones undergo smooth coupling with thiourea in the presence of 10 mol % of copper(II) triflate to produce the corresponding 2-aminothiazoles in excellent yields with high selectivity. The use of copper(II) triflate makes this method simple, convenient and practical. This method works well with both aryl and alkyl diazoketones to furnish a wide range of 2-aminothiazoles.
Aracyl triflates as derivatizing agents for biological betaines
Happer, D. Alan R.,Hayman, Colin M.,Storer, Malina K.,Lever, Michael
, p. 467 - 472 (2007/10/03)
Several trifluoromethanesulfonates of general structure ArCOCH 2OTf were prepared and their suitability for use as derivatizing agents for the HPLC analysis of betaines was assessed. Four of them (Ar=2′-naphthyl, 2′-fluorenyl, 6′-methoxynaphtha