40252-11-7

Upstream product

• 614-34-6 p-cresyl benzoate 
• 7726-95-6 bromine 
• 127-09-3 sodium acetate 
• 64-19-7 acetic acid 
• 87770-86-3 p-(hydroxymethyl)phenyl benzoate 
• 106-44-5 p-cresol 
• 98-88-4 benzoyl chloride 
• 5339-06-0 4-formylphenyl benzoate 

Downstream Products

• 756488-28-5 2-(4-benzoyloxy-benzyl)-malonic acid diethyl ester 
• 191987-22-1 N¹-[4-(benzoyloxy)benzyl]-N¹,N²-bis(tert-butyloxycarbonyl)guanidine 
• 40252-14-0 C₃₇H₂₆O₃ 
• 756488-29-6 2-[4-((2S,3R,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-3-hydroxy-tetrahydro-pyran-2-yloxy)-benzyl]-malonic acid diisopropyl ester 
• 756488-30-9 2-[4-((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-benzyl]-malonic acid diisopropyl ester 
• 77094-90-7 3-(4-hydroxyphenyl)-2-ethoxycarbonyl-propionic acid ethyl ester 

Relevant academic research and scientific papers

The β-glucuronyl-based prodrug strategy allows for its application on β-glucuronyl-platinum conjugates

The use of platinum drugs in antitumour therapy is well established. An important drawback of these chemotherapeutics is the lack of selectivity for tumour cells, usually resulting in severe toxic side effects. A glucuronyl-platinum conjugate was designed and synthesised to test the compatibility of platinum compounds with β-glucuronidase-based prodrug therapy. Instantaneous cleavage of the β-glucuronic bond in the glucuronyl-platinum conjugate was observed upon addition of β-glucuronidase resulting in PtII(dach)(4-hydroxybenzylmalonate) and glucuronic acid.

Nuclear versus side-chain bromination of 4-methoxy toluene by an electrochemical method

GRAPHICAL ABSTRACT The electrochemical bromination of 4-methoxy toluene by two-phase electrolysis yields 3-bromo 4-methoxy toluene at first, which subsequently undergoes side-chain bromination to give 3-bromo 4-methoxy benzyl bromide as a final product in 86% yield. The two-phase electrolysis consists of 25-50% NaBr as aqueous electrolyte and CHCl3 containing aromatic compound as organic phase. The reaction temperature is maintained at 10-25 °C. The probable orientation of bromine atom in an alkyl aromatic compound (nuclear versus side chain) is explained from the experimental result.

Reactions of difluorocarbene with organozinc reagents

Reactions of difluorocarbene with benzyl and alkylzinc halides leading to fluorinated organozinc species have been described. The generated α-difluorinated organozinc reagents are reasonably stable in solution and can be quenched with external electrophiles (iodine, bromine, proton), affording compounds containing the CF2 fragment.

A convenient method for the preparation of benzyl isocyanides

Treatment of benzyl halides with silver salts (AgClO4, AgBF 4, or AgOTf) and trimethylsilyl cyanide (TMSCN) in CH 2Cl2 followed by cleavage of the carbon-silicon bond with aqueous NaHCO3 or TBAF directly afforded the corresponding isocyanides. Georg Thieme Verlag Stuttgart.

Antiosteoporotic imidazo[4,5-c]pyridines

This invention relates to 2-substituted-imidazo[4,5 -c]pyridines, to the process for their preparation, to pharmaceutical compositions containing said 2-substituted-imidazo]4,5-c]pyridines and to the use of said 2-substituted-imidazo[4,5-c]pyridines for modifying the balance between bone production and bone resorption in a host animal, including man.