84184-50-9Relevant academic research and scientific papers
2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands
Lee, Jeewoo,Lee, Ju-Hyun,Kim, Su Yeon,Perry, Nicholas A.,Lewin, Nancy E.,Ayres, Jolene A.,Blumberg, Peter M.
, p. 2022 - 2031 (2007/10/03)
A series of 2-benzyl and 2-phenyl-3-hydroxypropyl pivalates designed to incorporate the principal pharmacophores of phorbol esters have been synthesized and tested as PKC-α ligands. Among the analogues, 13c exhibited the most potent binding affinity with a Ki = 0.7 μM. The synthesized analogues were subjected to molecular modeling analysis based on two alternative models of the phorbol pharmacophore and a docking study of 13c was carried out.
Aminobenzoic and aminocyclohexanecarboylic acid compounds, compositions, and their method of use
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, (2008/06/13)
Compounds of the formula inhibit the action of neutral endopeptidase. As a result, such compounds produce diuresis, natriuresis, and lower blood pressure as well as being useful in the treatment of congestive heart failure, relieving pain, and diarrhea when administered to a mammalian host.
Malonic acid derivatives and methods for their synthesis
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, (2008/06/13)
The present invention refers to a new class of malonic acid derivatives of general formula I STR1 wherein R1 and R2, each independently, represent hydrogen or a carboxyl protecting group, and the residue R corresponds to the side-cha
Studies on the Chemical Constituents of Rutaceous Plants. Part 45. Novel Phenyl Propanoids: Cuspidiol, Boninenal, and Methyl Boninenalate
Ishii, Hisashi,Ishikawa, Tsutomu,Tohojoh, Toshiaki,Murakami, Keiko,Kawanable, Eri,et al.
, p. 2051 - 2058 (2007/10/02)
Cuspidiol, boninenal, and methyl boninenalate were established as having the structures 3-phenyl>propanol (1), (E)-3-phenyl>propenal (2), and (E)-3-phenyl>propenal (3) respectively.The three compounds were also independently synthesized.
