77198-43-7

Upstream product

• 4354-73-8 2-(cyclohexylidene)malononitrile 
• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 
• 108-94-1 cyclohexanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 109-77-3 malononitrile 
• 836-41-9 p-methoxybenzylidene-phenylamine 
• 129224-53-9 2-cyano-2-cyclohexylidenethioacetamide 

Downstream Products

• 77198-61-9 2-amino-4-(4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalene-1,3-dicarbonitrile 

Relevant academic research and scientific papers

Synthesis of cobalt tetra-2,3-pyridiniumporphyrazinato with sulfonic acid tags as an efficient catalyst and its application for the synthesis of bicyclic: Ortho -aminocarbonitriles, cyclohexa-1,3-dienamines and 2-amino-3-cyanopyridines

Cobalt tetra-2,3-pyridiniumporphyrazinato with sulfonic acid tag [Co(TPPASO3H)]Cl was produced and catalyzed the synthesis of ortho-aminocarbonitriles, cyclohexa-1,3-dienamines and 2-amino-3-cyanopyridines. The synthesis of 2-amino-3-cyanopyridines by usi

A task-specific biodegradable ionic liquid: a novel catalyst for synthesis of bicyclic ortho-aminocarbonitriles

Abstract: Herein, we report a novel method for synthesis of bicyclic ortho-aminocarbonitriles catalyzed by biodegradable ionic liquid. The biodegradability (BOD analysis) of all the ionic liquids that are used to carry out the reaction is studied, and the

Multicomponent domino reactions in deep eutectic solvent: An efficient strategy to synthesize multisubstituted cyclohexa-1,3-dienamines

The multicomponent domino reactions of ketones, aldehydes and malononitrile in a deep eutectic solvent (DES) were developed. Urea-choline chloride based DES is effective dual solvents/organocatalysts and affording a series of multisubstituted cyclohexa-1,

Tandem synthesis of bicyclic ortho-aminocarbonitrile derivatives in ionic liquids

An efficient synthesis of 2-amino-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitriles via the tandem four-component condensation of one equivalent of aromatic aldehyde, cyclohexanone, and two equivalents of malononitrile in ionic liquids was underta

Borax catalyzed domino reactions: Synthesis of highly functionalised pyridines, dienes, anilines and dihydropyrano[3,2-c]chromenes

Borax, an innocuous, inexpensive, and a naturally occurring material, very efficiently catalyzes the Knoevenagel condensation and Michael addition in domino fashion for the construction of highly functionalised pyridines, dienes, anilines and dihydropyran

Novel [4 + 2] cycloaddition reaction of aryl-methylidenemalononitriles to unsaturated chalcogen amides. Synthesis, structure, and properties of triethylammonium 3,5,5-tricyano-1,4,5,6-tetrahydropyridine-2-selenolates and -thiolates

Reaction of arylmethylidenemalononitriles with 3-aryl-2-cyanoprop-2- eneselenoamides in the presence of Et3N gave triethylammonium 4,6-diaryl-3,5,5-tricyano-1,4,5,6-tetrahydropyridine-2-selenolates. A similar reaction with cyclohexylidenecyanothioacetamide yields triethylammonium 4-aryl-1,5,5-tri-cyano-3-azaspiro[5.5]undec-1-ene-2-thiolate. Alkylation of the obtained selenolates and thiolates gives 6-(alkylseleno)-2,4-diaryl-1,4- dihydropyridine-3,3,5(2H)-tricarbonitriles and 4-(alkylthio)-2-aryl-3-aza- spiro[5.5]undec-4-ene-1,1,5-tricarbonitriles, respectivelly. The structure of 2,4-di(2-furyl)-6-{[2-(4-methylphenyl)-2-oxoethyl]seleno}-1,4-dihydropyridine-3, 3,5(2H)-tricarbonitrile has been confirmed by the X-ray structural analysis.

Nitriles in Organic Synthesis: The Reaction of Cinnamonitriles with Cyclohexanone and Acetylacetone

The reaction of 1a,b with cyclohexanone afforded hexahydronaphthalene derivatives (3a,b).In contrast to the behaviour of 1a,b, cyclohexanone reacts with 4a-c to yield the propenylidenecyclohexanone derivatives (5a-c).The reaction of 1a with acetylacetone

CYCLIZATION REACTIONS OF NITRILES. III. SYNTHESIS OF o-CYANOANILINES BY THE THORPE REACTION

The reaction of alkylidenemalononitriles with arylidene derivatives of malononitrile and cyanoacetic ester leads to the formation of derivatives of 1-amino-2,6-dicyano-3,5-diaryl-1,3-cyclohexadiene or 2,4-dicyano-3-amino-5-arylbicyclodeca-2,10-dien