77198-61-9

Upstream product

• 108-94-1 cyclohexanone 
• 2286-29-5 ethyl 2-cyano-3-(4-methoxyphenyl)prop-2-enoate 
• 109-77-3 malononitrile 
• 77198-43-7 2-amino-4-(4-methoxyphenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 
• 129224-53-9 2-cyano-2-cyclohexylidenethioacetamide 

Relevant academic research and scientific papers

Novel [4 + 2] cycloaddition reaction of aryl-methylidenemalononitriles to unsaturated chalcogen amides. Synthesis, structure, and properties of triethylammonium 3,5,5-tricyano-1,4,5,6-tetrahydropyridine-2-selenolates and -thiolates

Reaction of arylmethylidenemalononitriles with 3-aryl-2-cyanoprop-2- eneselenoamides in the presence of Et3N gave triethylammonium 4,6-diaryl-3,5,5-tricyano-1,4,5,6-tetrahydropyridine-2-selenolates. A similar reaction with cyclohexylidenecyanothioacetamide yields triethylammonium 4-aryl-1,5,5-tri-cyano-3-azaspiro[5.5]undec-1-ene-2-thiolate. Alkylation of the obtained selenolates and thiolates gives 6-(alkylseleno)-2,4-diaryl-1,4- dihydropyridine-3,3,5(2H)-tricarbonitriles and 4-(alkylthio)-2-aryl-3-aza- spiro[5.5]undec-4-ene-1,1,5-tricarbonitriles, respectivelly. The structure of 2,4-di(2-furyl)-6-{[2-(4-methylphenyl)-2-oxoethyl]seleno}-1,4-dihydropyridine-3, 3,5(2H)-tricarbonitrile has been confirmed by the X-ray structural analysis.

Efficient NaOH-catalyzed reaction of aromatic aldehyde, cyclic ketones, and malononitrile under solvent-free conditions using a grinding method

An efficient and facile synthesis of 2,6-dicyanoanilines via a one-pot reaction of aromatic aldehydes, malononitrile, and cyclic ketones in the presence of NaOH under solvent-free conditions using a grinding method has been developed. Compared with the classical reaction conditions, the new synthetic method has the advantages of excellent yields, shorter reaction times, and mild reaction conditions. Copyright Taylor & Francis Group, LLC.

CYCLIZATION REACTIONS OF NITRILES. III. SYNTHESIS OF o-CYANOANILINES BY THE THORPE REACTION

The reaction of alkylidenemalononitriles with arylidene derivatives of malononitrile and cyanoacetic ester leads to the formation of derivatives of 1-amino-2,6-dicyano-3,5-diaryl-1,3-cyclohexadiene or 2,4-dicyano-3-amino-5-arylbicyclodeca-2,10-dien