77210-71-0

Upstream product

• 88-98-2 cyclohex-4-ene-1,2-dicarboxylic acid 
• 13287-81-5 4,5-bis(hydroxymethyl)-1-cyclohexene 
• 85-43-8 1,2,3,6-Tetrahydrophthalic anhydride 
• 497-23-4 2-buten-4-olide 
• 106-99-0 buta-1,3-diene 

Downstream Products

• 88586-06-5 (3aS,7aR)-3a,4,7,7a-tetrahydroisobenzofuran-1(3H)-one 
• 788121-64-2 (1S,6R)-6-Hydroxymethyl-cyclohex-3-enecarboxylic acid 
• 121961-83-9 Sodium; (1S,6R)-6-hydroxymethyl-cyclohex-3-enecarboxylate 
• 65376-02-5 (1S,6R)-8-oxabicyclo[4.3.0]nonan-7-one 
• 89395-29-9 (3aR,7aS)-hexahydroisobenzofuran-1-one 

Relevant academic research and scientific papers

Iron(II) pincer-catalyzed synthesis of lactones and lactams through a versatile dehydrogenative domino sequence

The synthesis of lactones and lactams by using iron(II) pincer-catalyzed dehydrogenative methodology was developed. Starting from 1,n-diols or 1,n-amino alcohols, this domino transformation takes place through initial dehydrogenation of the substrates, subsequent intramolecular cyclization, and final oxidation to afford the desired products in good yields. The ability to access heterocycles of different sizes makes this protocol especially versatile, in which two consecutive oxidation reactions are performed without requiring an external oxidant. In this paper, we report the application of the Fe-MACHO-BH complex [carbonylhydrido(tetrahydroborato)[bis(2-diisopropylphosphinoethyl)amino]iron(II)] in this atom-efficient and environmentally benign process, for which molecular hydrogen is formed as the only stoichiometric side product. Just a little pinch: The iron(II) pincer-catalyzed synthesis of lactones and lactams from easily available 1,n-diols and 1,n-amino alcohols is explored. The use of a nontoxic metal as well as the generation of molecular hydrogen as the only stoichiometric byproduct makes this method a highly atom-efficient and environmentally benign process.

[6-(substituted-methyl)-3-cyclohexenyl] formamide derivative, hair growth promoter and external composition for skin

A [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C10-30expressed by R1and the other is—(CH2)n-NR2

Construction of bicyclo[2.2.2]octane ring system via homoallyl-homoallyl radical rearrangement

We designed a sequential three-step, one-pot reaction (homoallyl- homoallyl radical rearrangement reaction) to generate highly functionalized bicyclo[2.2.2]octane ring system, and succeeded in developing a novel synthetic method to bicyclo[2.2.2]octane compounds from simple cyclohexene derivatives.