13287-81-5

Usage

Uses

Used in Chemical Synthesis:
4-Cyclohexene-1,2-dimethanol is used as a solvent and intermediate for the synthesis of various chemicals. Its solubility in water and versatility in chemical reactions make it a valuable component in the production of a wide range of compounds.
Used in Pharmaceutical Industry:
4-Cyclohexene-1,2-dimethanol is used as a key component in the synthesis of pharmaceuticals. Its ability to participate in various chemical reactions allows for the creation of diverse drug molecules, contributing to the development of new medications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Cyclohexene-1,2-dimethanol is utilized as a precursor in the production of various agrochemicals. Its role in the synthesis of these compounds aids in the development of effective products for agricultural applications.
Used in Flavor Industry:
4-Cyclohexene-1,2-dimethanol is employed as a building block in the creation of flavors. Its chemical properties enable the formation of unique flavor compounds, enhancing the taste profiles of various food and beverage products.
Used in Safety and Handling:
4-Cyclohexene-1,2-dimethanol is used as a reminder of the importance of safety and proper handling procedures in industries where it is utilized. Its potential harmful effects and ability to cause irritation necessitate the implementation of safety measures to protect workers and the environment.

Upstream product

• 85-43-8 1,2,3,6-Tetrahydrophthalic anhydride 
• 4841-85-4 trans-1,2-bis(ethoxycarbonyl)-4-cyclohexene 
• 88-98-2 trans-cyclohex-4-ene-1,2-dicarboxylic acid 
• 17673-68-6 dimethyl trans-cyclohex-4-ene-1,2-dicarboxylate 
• 85-43-8 trans-4-Cylohexene-1,2-dicarboxylic anhydride 
• 88-98-2 cyclohex-4-ene-1,2-dicarboxylic acid 

Downstream Products

• 98516-11-1 acetic acid (1S,6R)-6-hydroxymethyl-cyclohex-3-enylmethyl ester 
• 76155-27-6 (+/-)-trans-2-(hydroxymethyl)cyclohexylmethanol 
• 56799-21-4 trans-6-Hydroxy-3-cyclohexen-1-carbaldehyd 
• 87338-23-6 4-cyclohexene-1,2-dimethanol dimethanesulfonate 
• 15679-28-4 ((1R,6R)-6-(hydroxymethyl)cyclohex-3-enyl)methanol 
• 15679-27-3 (4S,5S)-4,5-bis(hydroxymethyl)cyclohexene 
• 82864-75-3 (1R,6R)-6-Hydroxymethyl-cyclohex-3-enecarboxylic acid 
• 3470-42-6 trans-8-oxabicyclo<4.3.0>non-3-ene 
• 52811-30-0 trans-4-(cis-1-Propenyl)-5-vinylcyclohexen 
• 52811-30-0 (+/-)-aucantene 
• 56799-25-8 trans-6-Vinyl-3-cyclohexen-1-carbaldehyd 
• 56799-24-7 trans-6-Vinyl-3-cyclohexen-1-methanol 
• 3685-01-6 trans-4,5-dimethylcyclohexene 

Relevant academic research and scientific papers

Polycyclic amide derivative as CDK9 inhibitor, and preparation method and application thereof

The invention belongs to the technical field of polycyclic amide derivatives, and particularly relates to a polycyclic amide derivative as a CDK9 inhibitor, and a preparation method and application thereof. The polycyclic amide derivative shows excellent CDK9 enzyme inhibitory activity, and can be used for preparing drugs for treating cancers, especially hematologic cancers including acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma and the like and solid tumors, such as acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia and follicular lymphoma, including breast cancer, prostate cancer, ovarian cancer, hepatocellular carcinoma, pancreatic cancer, kidney cancer, stomach cancer, colorectal cancer, lung cancer and the like.

Iron(II) pincer-catalyzed synthesis of lactones and lactams through a versatile dehydrogenative domino sequence

The synthesis of lactones and lactams by using iron(II) pincer-catalyzed dehydrogenative methodology was developed. Starting from 1,n-diols or 1,n-amino alcohols, this domino transformation takes place through initial dehydrogenation of the substrates, subsequent intramolecular cyclization, and final oxidation to afford the desired products in good yields. The ability to access heterocycles of different sizes makes this protocol especially versatile, in which two consecutive oxidation reactions are performed without requiring an external oxidant. In this paper, we report the application of the Fe-MACHO-BH complex [carbonylhydrido(tetrahydroborato)[bis(2-diisopropylphosphinoethyl)amino]iron(II)] in this atom-efficient and environmentally benign process, for which molecular hydrogen is formed as the only stoichiometric side product. Just a little pinch: The iron(II) pincer-catalyzed synthesis of lactones and lactams from easily available 1,n-diols and 1,n-amino alcohols is explored. The use of a nontoxic metal as well as the generation of molecular hydrogen as the only stoichiometric byproduct makes this method a highly atom-efficient and environmentally benign process.

[6+5] FUSED BICYCLES AS A THROMBIN ANTAGONIST, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE BICYCLES

The present invention relates to the new [6+5] fused bicycle derivatives, pharmaceutically acceptable salts or isomers thereof, processes for preparing the same, and pharmaceutical compositions comprising the same. The [6+5] fused bicycle derivatives can antagonize the thrombin receptor and thus may be effectively used for the treatment and prevention of thrombus, platelet aggregation, atherosclerosis, restenosis, blood coagulation, hypertension, arrhythmia, angina pectoris, heart failure, inflammation and cancer when used alone or with other cardiovascular agents.

Reactivity of N-alkanoyloxy-2,2,6,6-tetramethylpiperidines (O-acylTEMPOs) towards hydride-transferring or metallic alkylating reagents; unprecedented stability and application to chemoselective transformations

Owing to the unprecedented stability of O-acylTEMPOs towards hydride-transferring and metallic alkylating reagents such as LiAlH4 and RMgX, chemoselective transformation of diacid mixed alkyl/TEMP-1-yl esters, where O-acylTEMPOs remained intact, is achieved with these reagents, giving the corresponding carbinols, respectively.

Complete relative stereochemistry of maitotoxin

By addressing the relative stereochemistry of the four acyclic portions via organic synthesis, the complete relative stereochemistry of maitotoxin (MTX) has been established as 1B. The relative stereochemistry of the C.1-C.15 portion was elucidated via a two-phase approach: (1) the synthesis of the eight diastereomers possible for model C, representing the C.1-C.11 portion, and the eight diastereomers possible for model D, representing the C.11-C.15 portion, and the comparison of their proton and carbon NMR characteristics with those of MTX, concluding that 9 and 35 represent the relative stereochemistry of the corresponding portions of MTX; (2) the synthesis of the two remote diastereomers 51 and 52, and comparison of their proton and carbon NMR characteristics with those of MTX, concluding that 51 represents the relative stereochemistry of the C.1-C.15 portion of MTX. The relative stereochemistry of the C.35-C.39, C.63-C.68, and C.134-C.142 acyclic portions was established via (1) the synthesis of the 8, 8, and 16 diastereomers possible for models E, F, and G, respectively, and (2) the comparison of their proton and carbon NMR characteristics with those of MTX, concluding that 81, 117, and 187, respectively, represent the relative stereochemistry of the corresponding portions of MTX. Some biogenetic considerations have been given to speculate on the absolute configuration of MTX. The vicinal proton coupling constants observed for models 51, 81, 117, and 187 were used to elucidate their preferred solution conformation. Assembling the preferred solution conformations found for the four acyclic portions allows one to suggest that the approximate global conformation of MTX is represented by the shape of a hook, with the C.35-C.39 portion being its curvature. MTX appears to be conformationally relatively rigid, except for conformational flexibility around the C.7-C.9 and C.12-C.14 portions. On the basis of the experimental results gained in the current work, coupled with those in the AAL-toxin/fumonisin area, it has been pointed out that the structural properties of 51, 81, 117, 187 and their diastereomers are inherent to the specific stereochemical arrangement of the small substituents on the carbon backbone and are independent from the rest of the molecule. Thus, it has been suggested that each of these diastereomers has the capacity to install a unique structural characteristic through a specific stereochemical arrangement of substituents on the carbon backbone, and that fatty acids and related classes of compounds may be able to carry specific information and serve as functional materials in addition to structural materials.

Total synthesis of Taxol. 2. Construction of A and C ring intermediates and initial attempts to construct the ABC ring system

A method for the formation of Taxol's ABC ring system has been developed. General methods for the synthesis of versatile synthons for Taxol's A ring (8) and C ring (55) are presented. A model study using a simplified C ring synthon (17) confirmed the viability of the sequential Shapiro-McMurry strategy for formation of Taxol's B ring. Careful exploration of the chemistry of various A-B ring conjugates allowed the development of a successful method for formation of the B ring in a more functionalized system.

Cyclisation concertee d'homologues cyclohexaniques et cyclohexeniques du chloro-4 butanol: enthalpies et entropies d'activation; modelisation du chemin reactionel; evolutions d'etats de transition

The relative stabilities of cis and trans stereoisomers of 1-chloromethyl-2-hydroxymethyl cyclohexane and of 4-chloromethyl-5-hydroxymethyl cyclohexene, and of their related bicyclic ethers, have been calculated using the MM2 molecular mechanics program.T

Enantioselectivity of the Microsomal Epoxide Hydrolase Catalyzed Hydrolysis of trans-4,5-Dimethyl-1,2-epoxycyclohexane

The hydrolysis of the racemic and enantiomeric forms of trans-4,5-dimethyl-1,2-epoxycyclohexane, catalyzed by rabbit liver microsomal epoxide hydrolase (EH), has been investigated to clarify further the mechanism of enantioselection by this enzyme.Both ac

SILICIUMORGANISCHE VERBINDUNGEN. LXXIII. HYDRIERTE 2,4-DIOXA-SILEPINE, -SILOCINE UND -SILONINE

Silylation of the diols I-V with hexamethylcyclotrisilazane (VI) leads to the 3,3-dimethyl derivatives of hydrogenated 2,4-dioxa-cis- (VII) and -trans-benzo-(VIII), -cyclohexene- (IX), -cyclohexadieno- (X) and -naphtho-3-silepines (XI).The diols XVIII and