77341-09-4

Usage

Uses

Used in Pharmaceutical Industry:
3-triMethylsilyloxy-7-ketolithocholic Methyl ester is used as a reactant in the preparation of Obeticholic Acid for the treatment of primary biliary cirrhosis and other liver diseases. Its unique chemical structure allows for the synthesis of Obeticholic Acid, which has therapeutic effects on liver function and overall health.

Upstream product

• 10416-59-8 N,O-bis-(trimethylsilyl)-acetamide 
• 10538-59-7 7-ketolithocholic methyl ester 
• 474-25-9 chenodeoxycholic acid 
• 4651-67-6 7-Ketolithocholic acid 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 915038-24-3 (E/Z)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid 
• 863239-59-2 3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Crystal form H of 3 alpha,7 alpha-dihydroxyl-6 alpha-ethyl-5 beta-cholanic acid as well as preparation method and application of crystal form H

The invention provides a novel crystal form, namely a crystal form H, of 3 alpha,7 alpha-dihydroxyl-6 alpha-ethyl-5 beta-cholanic acid and further provides a preparation method of the crystal form H of 3 alpha,7 alpha-dihydroxyl-6 alpha-ethyl-5 beta-cholanic acid. The crystal form H of 3 alpha,7 alpha-dihydroxyl-6 alpha-ethyl-5 beta-cholanic acid, disclosed by the invention contains no crystal solvents or water, has a good crystal form and is good in stability, not easy to absorb moisture, suitable for recrystallization purification and capable of effectively removing impurities.

Process for preparing aobeiAobei cholic acid (by machine translation)

The invention application discloses a process for preparing aobeiAobei cholic acid, includes the following steps: AB - 1 — AB - 2 — AB - 3 — AB - 4 — AB - 5 — AB - 6 — AB - 7 — AB - 8 — AB - 9 — AB - 10, the preparation process in the process of preparing a simple and highly efficient reaction conditions, so as to ensure that the quality of the final product aobeiAobei cholic acid can be controlled. (by machine translation)

PROCESS FOR PREPARATION OF OBETICHOLIC ACID

The invention of the present application relates to the process for the preparation of intermediates of obeticholic acid and their conversion to obeticholic acid. The process involves the conversion of compound of formula (VI) to compound of formula (VII) in presence of an organic base.

METHODS OF PROMOTING HEPATIC REGENERATION

The present invention relates to methods of accelerating, promoting or increasing hepatic regeneration, or increasing liver mass in a subject, by using a compound of formula (A): or a pharmaceutically acceptable salt thereof, and wherein R1, R2, R3, R4, R5, R6, m, and n are as described herein.

Method for preparing 3,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate

The invention belongs to the technical field of medicines, and relates to a method for preparing 3,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate. Preferentially, 3,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate is 3 alpha,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate. According to the method, 3,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate, especially 3 alpha,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate, prepared through the method can be used for preparing obeticholic acid.

Treatment of Pulmonary Disease

The present invention relates to methods of treating, reducing the risk of preventing, or alleviating a symptom of a pulmonary disease or condition, reducing or suppressing inflammation in the lung, and promoting lung repair, by using a compound of formula A: or a pharmaceutically acceptable salt thereof.