77367-70-5

Upstream product

• 533-75-5 2-hydroxy-2,4,6-cycloheptatrien-1-one 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 

Downstream Products

• 36841-98-2 2-cyclohexylcyclohepta-2,4,6-trien-1-one 
• 62412-12-8 2-(benzyloxy)-7-bromocyclohepta-2,4,6-trien-1-one 
• 1946-74-3 2-hydroxy-3-isopropyl-2,4,6-cycloheptatrien-1-one 
• 126385-38-4 3-Benzyl-2-methoxy-cyclohepta-2,4,6-trienone 
• 126385-39-5 5-Benzyl-2-methoxy-cyclohepta-2,4,6-trienone 
• 126385-37-3 2-benzyl-7-methoxy-tropone 
• 75-18-3 dimethylsulfide 
• 533-75-5 2-hydroxy-2,4,6-cycloheptatrien-1-one 
• 100-52-7 benzaldehyde 
• 77367-77-2 3-benzyl-tropolone 

Relevant academic research and scientific papers

TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS

Disclosed are a series of compounds or their tautomers having a general structure represented by Formula (la), (lb), (Ila), (lIb), or (lIc) and pharmaceutically acceptable salts thereof. The present disclosure also relates to pharmaceutical compositions comprising said compounds or tautomers. The present disclosure further relates to a method of treating a disease or condition associated with iron dysregulation or dysfunctional iron homeostasis comprising administering to a subject in need thereof a therapeutically effective amount of Formula (la), (lb), (Ila), (lIb), or (lIc) compounds or tautomers.

Synthesis and in vitro protozoocidal evaluation of novel diazabicyclic tropolone derivatives

The synthesis and in vitro antiparasitic activity of twenty-seven novel diazabicycles based on tropolone ethers is presented. The compounds can be readily prepared by means of a high-yielding hetero Diels-Alder reaction using simple and readily available starting materials. Several of the new diazabicycles have in vitro activities against Trypanosoma cruzi, Leishmania donovani, Trypanosoma brucei rhodesiense, and chloroquine-resistant Plasmodium falciparum that are comparable or superior to those of currently employed protozoocidal agents.

Fungicidal activity of β-thujaplicin analogues

The fungicidal activity of analogues of β-thujaplicin, a natural product responsible for the durability of heartwood of several cupressaceous trees, was investigated in vitro on the growth of different white and brown rot fungi involved in wood biodegradation, Coriolus versicolor, Phanerochaete chrysosporium, Poria placenta and Gloephyllum trabeum. The study shows that 2-hydroxycyclohepta-2,4,6-trienone (tropolone), easily prepared according to a literature procedure, possesses interesting fungicidal activity when compared to β-thujaplicin, azaconazole, tebuconazole and copper oxine, which suggests this compound should be examined further as a potential biocide for wood preservation.

Synthesis and biological evaluation of O-alkylated tropolones and related α-ketohydroxy derivatives as ribonucleotide reductase inhibitors

A series of O-alkylated tropolones and related α-ketohydroxy compounds were evaluated for their biological activities and were shown to present an expected ribonucleotide reductase inhibition and cytotoxicity against some cancer cell lines but no antitubulin activity. Pharmacomodulation studies were realised to understand and enhance the observed activities. These original benzylic, heterocyclic and allylic compounds have been synthesised by a phase-transfer catalysed O-alkylation developed in our laboratories.

Asymmetric induction with cyclodextrins: Photocyclization of tropolone alkyl ethers

Employing the photobehavior of tropolone alkyl ethers as the probe, we have established that cyclodextrins could as a serve as medium to bring about enantioselective photoreactions. The enantioselectivity observed in this study is moderate at best. The enantioselectivity observed in the solid state in comparison to aqueous solution suggests that a rigid environment may be essential to achieve chiral induction during photoreactions of organic molecules. In this context the much higher enantioselectivity observed for the same systems within zeolites is noteworthy. (C) 2000 Elsevier Science Ltd.

A convenient method for the alkylation of tropolone derivatives and related α-keto hydroxy compounds

A mild and general method of phase-transfer catalyzed O-alkylation of biologically promising tropolones with allyl, benzyl and heterocyclic primary halides was developed. This method was also applied successfully to various substituted or ring-fused tropo

A CONVENIENT ROUTE TO TROPOLONE ETHERS

A general synthesis of tropolone ethers employing the reaction of tropolone with potassium carbonate, an alkyl halide and dicyclohexyl-18-crown-6 in acetonitrile solvent is described.