7739-06-2Relevant articles and documents
A rapid and efficient method for the reduction of quinoxalines
McKinney, Andrew M.,Jackson, Kevin R.,Salvatore, Ralph Nicholas,Savrides, Elena-Maria,Edatte, Mary Jane,Gavin, Terrence
, p. 1031 - 1034 (2005)
Mono and di-substituted alkyl and aryl quinoxalines are rapidly reduced in high yield to their respective 1,2,3,4-tetrahydro-derivatives by borane in THF solution. In the case of the 2,3-di-substituted compounds, reduction is stereoselective yielding excl
Asymmetric Transfer Hydrogenations of 2,3-Disubstituted Quinoxalines with Ammonia Borane
Li, Songlei,Meng, Wei,Du, Haifeng
, p. 2604 - 2606 (2017/05/24)
An asymmetric transfer hydrogenation of 2,3-disubstituted quinoxalines using a chiral frustrated Lewis pair of Piers' borane and (R)-tert-butylsulfinamide as the catalyst with ammonia borane as the hydrogen source has been successfully realized. For 2-alk
A highly cis-selective and enantioselective metal-free hydrogenation of 2,3-disubstituted quinoxalines
Zhang, Zhenhua,Du, Haifeng
, p. 623 - 626 (2015/03/04)
A wide range of 2,3-disubstituted quinoxalines have been successfully hydrogenated with H2 using borane catalysts to produce the desired tetrahydroquinoxalines in 80-99% yields with excellent cis selectivity. Significantly, the asymmetric reaction employing chiral borane catalysts generated by the in situ hydroboration of chiral dienes with HB(C6F5)2 under mild reaction conditions has also been achieved with up to 96% ee, and represents the first catalytic asymmetric system to furnish optically active cis-2,3-disubstituted 1,2,3,4-tetrahydroquinoxalines.
