77513-58-7

Basic information

• Product Name: ethyl (±)-tetrahydro-2-oxo-3-furoate
• Synonyms: ethyl (±)-tetrahydro-2-oxo-3-furoate;(±)-Tetrahydro-2-oxo-3-furancarboxylic acid ethyl ester;Ethyl 2-oxotetrahydrofuran-3-carboxylate
• CAS NO: 77513-58-7
• Molecular Formula: C₇H₁₀O₄
• Molecular Weight: 158.1519
• EINECS: 278-703-9
• Mol File: 77513-58-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 140 °C(Press: 10 Torr)
• Appearance: /
• Density: 1.1870 g/cm3(Temp: 17 °C)
• Storage Temp.: 2-8°C
• PKA: 13.15±0.20(Predicted)
• CAS DataBase Reference: ethyl (±)-tetrahydro-2-oxo-3-furoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (±)-tetrahydro-2-oxo-3-furoate(77513-58-7)
• EPA Substance Registry System: ethyl (±)-tetrahydro-2-oxo-3-furoate(77513-58-7)

Safety Data

• Hazardous Substances Data: 77513-58-7(Hazardous Substances Data)

Usage

General Description

Ethyl (±)-tetrahydro-2-oxo-3-furoate is a chemical compound that belongs to the furan derivatives family. It is a colorless liquid with a fruity odor and is commonly used in the flavor and fragrance industry. ethyl (±)-tetrahydro-2-oxo-3-furoate is also used as a food additive to impart sweet and fruity flavors to various products. It can be found in a wide range of food and beverage such as fruit-flavored drinks, candies, and baked goods. Additionally, it is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and as a solvent for chemical reactions. Ethyl (±)-tetrahydro-2-oxo-3-furoate is also used in the production of perfumes due to its pleasant and fruity aroma.

Upstream product

• 96-48-0 4-butanolide 
• 105-58-8 Diethyl carbonate 
• 63972-17-8 1,3-diethyl 2-(2-hydroxyethyl)propanedioate 
• 120-92-3 cyclopentanone 
• 66909-41-9 O-ethyl S-(tetrahydro-2-oxo-3-furanyl) thiocarbonate 
• 623-49-4 ethyl cyanoformate 
• 105-53-3 diethyl malonate 
• 71172-76-4 ethyl 2-ethoxycarbonyl-4-vinyloxybutyrate 
• 540-51-2 2-bromoethanol 
• 1559-02-0 diethyl cyclopropane-1,1-dicarboxylate 
• 75-21-8 oxirane 
• 996-82-7 sodium diethylmalonate 
• 500310-01-0 Ethyl (2-chloroethyl) malonate 

Downstream Products

• 23339-57-3 7-phenethyl-2-oxa-7-aza-spiro[4.4]nonane-1,6-dione 
• 33178-00-6 3-methyl-4-phenyl-2,7-dioxa-3-aza-spiro[4.4]nonane-1,6-dione 
• 82672-09-1 3-ethyl-2-oxotetrahydrofuran-3-carboxylic acid ethyl ester 
• 68975-07-5 3-benzyltetrahydrofuran-2-one 
• 5161-99-9 3-methyl-3-carboxyethyl-furan-2-one 

Relevant articles and documents

COMPOUNDS, COMPOSITIONS, AND METHODS

The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, deuterated analog, prodrug, tautomer, stereoisomer, or mixture of stereoisomers thereof, and methods of making and using thereof.

Sml2-mediated carbon-carbon bond fragmentation in a-aminomethyl malonates

A new and efficient samarium diiodide-promoted carbon-carbon bond fragmentation reaction of α-aminomethyl malonates, taking place normally at room temperature and generating the corresponding deaminomethylation products In 74-94% yields, is reported. The presence of the amino group Is necessary for the success of the current transformation.

Titanocene-Catalyzed Reduction of Lactones to Lactols

A convenient method for the conversion of lactones to lactols is described. The hydrosilylation to lactols is carried out via air-stable titanocene difluoride or a titanocene diphenoxide precatalyst using inexpensive polymethylhydrosiloxane (PMHS) as the stoichiometric reductant. These procedures have been demonstrated with a variety of substrates and proceed in good to excellent yield.