77607-69-3

Upstream product

• 114570-69-3 3-(2-furyl)-1-(4-methoxyphenyl)propen-1-one 
• 109-77-3 malononitrile 
• 5066-65-9 (E)-3-(furan-2-yl)-1-(4-methoxyphenyl)prop-2-en-1-one 
• 15147-20-3 1-(furan-2-yl)-3-(4-methoxyphenyl)prop-2-yn-1-one 

Downstream Products

• 276680-11-6 2-Amino-4-furan-2-yl-6-(4-methoxy-phenyl)-nicotinamide 
• 276680-20-7 4-amino-5-furan-2-yl-7-(4-methoxy-phenyl)-1H-pyrido[2,3-d]pyrimidine-2-thione 
• 276680-25-2 5-furan-2-yl-4-imino-3,7-bis-(4-methoxy-phenyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidine-2-thione 
• 276680-16-1 5-furan-2-yl-3,7-bis-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 

Relevant academic research and scientific papers

Synthesis and Antimicrobial Evaluation of Some Novel Pyrido[2,3-d] Pyrimidine Derivatives and Their Ribofuranosides

2-Amino-3-cyano-4,6-disubstituted pyridines 2a–c on treatment with arylisocyanate and arylisothiocyanate afforded 4-imino-3,5,7-trisubstituted pyrido[2,3-d] pyrimidin-2(1H)-ones 3a–c and 4-imino-3,5,7-trisubstituted pyrido[2,3-d]pyrimidin-2(1H)-thiones 4a

Synthesis of Some Novel Pyrido[2,3-d]pyrimidine and Pyrido[3,2-e][1,3,4]triazolo and Tetrazolo[1,5-c]pyrimidine Derivatives as Potential Antimicrobial and Anticancer Agents

A novel series of pyrido[2,3-d]pyrimidines 3a–d, 4a–d, 5a–d, 6a–d, and 7a–d; pyrido[3,2-e][1,3,4]triazolo; and tetrazolo[1,5-c]pyrimidines 10a–d and 11a–d was synthesized through different chemical reactions starting from 2-amino-3-cyano-4,6-diarylpyridines. The newly synthesized heterocycles were characterized by elemental analysis, IR, 1H-NMR, 13C-NMR, and mass spectral data. Compounds have been screened for their antibacterial and antifungal activities. The data showed that the presence of electron-donating group such as p-methoxyphenyl increases the antimicrobial activity. Also, the compounds have shown anticancer activity for colon and liver cancer cells.

Synthesis of nucleosides of pyrido-pyrimidines and their microbial activity

The nucleosides, 4-amino-5, 7-disubstituted-1-pyrido-pyrimidin-2-ones/thiones 6 and 7 and 3,5,7-trisubstituted-1-(β-D-ribofuranosyl>-pyrido pyrimidine-2, 4(3H)-diones 8 have been synthesized from 5,7-disubstituted pyrido--pyrimidin-2(1H)-ones/thiones 3 and 4 and 3,5,7-trisubstituted-1H, 3H-pyridopyrimidine-2,4-diones 5 respectively.The structures of the synthesized nucleosides and their precursors have been established by IR, 1H NMR and elemental analysis.These compounds have been tested for their antibacterial and antifungal activity and are found to be better antibacterial and antifungal agents than their precursors pyridopyrimidines.

Synthesis of some 5-furfuryl pyrido[2,3-d] pyrimidines and 1-ethyl-5-furfuryl pyrido[2,3-d] pyrimidines as possible antitumor & anticancer agents

Synthesis of some novel 5-furfuryl pyrido[2,3-d]pyrimidines was carried out by the condensation of 2-amino-3-cyano-4-furfuryl-6-substituted pyridine with various arylisothiocyanates, thiourea and carbondisulphide. These compounds on treatment with ethylbromide using phase transfer catalyst gave 1-ethyl-5-furfuryl pyrido[2,3-d]pyrimidines. The structure of the compounds has been established by elemental, IR and NMR studies. The compounds thus synthesized were screened for their antimicrobial activity.

Malononitriles & Cyanoesters : Part VI - Synthesis of New Biologically Active Cyanopyridines

3-(2'-Furyl)- and 3-(2'-thienyl)-acrylophenones (I) react with malononitrile in the presence of ammonium acetate to give 2-amino-3-cyano-4,6-disubstituted-pyridines (II).The latter are hydrolysed with alkali to give the corresponding nicotinamides (IV).Th