77629-84-6

Upstream product

• 136878-04-1 C₁₁H₁₃O₃⁽¹⁺⁾ 
• 107445-17-0 ethyl 2-diazo-2-(4-methoxyphenyl) acetate 
• 14062-18-1 ethyl p-methoxyphenylacetate 

Downstream Products

• 77648-21-6 ethyl 2-amino-2-(4-methoxyphenyl) acetate 
• 77047-71-3 α-azido-4-methoxyphenylacetic acid 
• 874-90-8 4-methoxybenzonitrile 
• 77629-86-8 N-(3-Bromopropionyl)-2-(p-methoxyphenyl)glycine Ethyl Ester 
• 148000-82-2 2-acetamido-2-(4'-methoxyphenyl)acetate d'ethyle 
• 136603-01-5 2-phenyl-4-(p-methoxyphenyl)-4H-oxazolin-5-one 
• 52771-14-9 2-acetamido-2-(4-methoxyphenyl) acetic acid 
• 56674-30-7 2-(benzamido)-2-(4-methoxyphenyl) acetic acid 
• 869470-48-4 ethyl 2-(benzamido)-2-(4-methoxyphenyl) acetate 
• 869470-04-2 2-methyl-4-(p-methoxyphenyl)-4H-oxazolin-5-one 
• 77629-82-4 Hydrotosylate salt of 2-(p-Methoxyphenyl)glycine Ethyl Ester 

Relevant academic research and scientific papers

Pd-catalyzed divergent C(sp2)-H Activation/Cycloimidoylation of 2-Isocyano-2,3-diarylpropanoates

A Pd-catalyzed site-selective C(sp2)-H activation/cycloimidoylation of 2-isocyano-2,3-diarylpropanoates to construct diverse cyclic imine products has been developed. Six-membered 3,4-dihydroisoquinolines containing a C3 quaternary carbon cente

Boron-Catalyzed Azide Insertion of α-Aryl α-Diazoesters

A challenging metal-free azide insertion of α-aryl α-diazoesters in the presence of B(C6F5)3 (5 mol %) was developed for the first time. The reaction features an easy operation, wide substrate scope, and mild conditions an

Synthesis ofα-azido ketones and esters using recyclable hypervalent iodine reagent

A simple and mild method for the preparation of αazido ketones and esters using hypervalent iodine reagent, 4,4'-bis-(dichloroiodo)-biphenyl, and sodium azide in 1,4-dioxane is discussed. Advantages of this system are easy workup, recyclable reagent, and

Diastereochemical diversity of imidazoline scaffolds via substrate controlled TMSCI mediated cycloaddition of azlactones

(Chemical Equation Presented) We report herein a trimethylsilyl chloride mediated substrate controlled 1,3-dipolar cycloaddition for the diastereoselective synthesis of either syn- or anti-imidazolines. This method provides scaffolds with four points of diversity and control over two stereocenters.

The Effects of α-Substituents on the Kinetic and Thermodynamic Stability of 4-Methoxybenzyl Carbocations: Carbocation Lifetimes That Are Independent of Their Thermodynamic Stability

The following new rate constants for reaction of α-substituted 4-methoxybenzyl carbocations, 4-MeOC6H4CR1(R2)(1+), with a solvent of 50:50 (v/v) trifluoroethanol/water at 25 deg C and ionic strength 0.50 (NaClO4) are reported: 4-MeOC6H4CH(OMe)(1+), Ks = 2.2E7 s-1; 4-MeOC6H4CH(N3)(1+), ks = 3.3E5 s-1; 4-MeOC6H4C(CH3)2(1+), ks = 1.3E7 s-1; 4-MeOC6H4CH(CO2Et)(1+), ks = 1.4E7 s-1; 4-MeOC6H4CCH3(CF3)(1+), ks = 2.5E7 s-1.The values of ks for reaction of 4-MeOC6H4CR1(R2)(1+) with 50:50 (v/v) trifluoroethanol/water are nearly independent of very large changes in the thermodynamic stability of these carbocations caused by the addition of a wide range of electron-withdrawing or electron-donating groups at the α-position.In the most extreme case, the change from an α-methoxy to two α-(trifluoromethyl) substituents leads to a 23 kcal/mol thermodynamic destabilization of 4-MeOC6H4CR1(R2)(1+) relative to the neutral azide ion adducts but a 5-fold decrease in its reactivity toward solvent.The data show that the effects of α-substituents on the kinetic stability of 4-MeOC6H4CR1(R2)(1+) are complex and do not parallel the thermodynamic stability of these carbocations.The results are explained by consideration of the polar and resonance effects of the α-substituents on both the thermodynamic driving force and the intrinsic barrier for capture of the carbocations by solvent.These reactions are a new example of the consequences of the "principle of nonperfect synchronization".