56674-30-7

Upstream product

• 19791-95-8 α-hydroxyhippuric acid 
• 100-66-3 methoxybenzene 
• 1027195-04-5 4-(4-Methoxy-phenyl)-5-oxo-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid ethyl ester 
• 201230-82-2 carbon monoxide 
• 183718-81-2 (E)-N-(4-methoxybenzylidene)benzamide 
• 104-87-0 4-methyl-benzaldehyde 
• 55-21-0 benzamide 
• 869470-48-4 ethyl 2-(benzamido)-2-(4-methoxyphenyl) acetate 
• 153397-31-0 4-Ethoxycarbonyl-2-phenyl-4,5-dihydrooxazol-5-one 
• 18649-43-9 4-methoxyphenyllead(IV) triacetate 
• 4461-33-0 benzoyl isocyanate 
• 77629-84-6 (±)-ethyl 2-azido-2-(4-methoxyphenyl)acetate 
• 77629-83-5 ethyl 2-bromo-2-(4-methoxyphenyl) acetate 
• 14062-18-1 ethyl p-methoxyphenylacetate 

Downstream Products

• 136603-01-5 2-phenyl-4-(p-methoxyphenyl)-4H-oxazolin-5-one 
• 136603-03-7 4,4'-Bis-<2-phenyl-4-p-methoxyphenyl-2-oxazolin-5-one> 

Relevant academic research and scientific papers

Diastereochemical diversity of imidazoline scaffolds via substrate controlled TMSCI mediated cycloaddition of azlactones

(Chemical Equation Presented) We report herein a trimethylsilyl chloride mediated substrate controlled 1,3-dipolar cycloaddition for the diastereoselective synthesis of either syn- or anti-imidazolines. This method provides scaffolds with four points of diversity and control over two stereocenters.

N-Acyl imine and enamide intermediates in the palladium-catalyzed amidocarbonylation reaction

N-Acyl imines and enamides have been synthesized and subjected to the reaction conditions for palladium-catalyzed amidocarbonylation of aldehydes. These compounds were competent substrates resulting in the formation of N-acyl amino acids; however, the presence of water was found to be necessary. Direct study of the same amidocarbonylation reaction revealed that enamides could be detected during the course of the reaction. A slight enhancement in the yield of the amidocarbonylation is observed in the presence of radical inhibitors ruling out a meaningful radical pathway. The results are most consistent with a mechanism involving complex equilibration of the starting materials to a number of intermediates which can converge to a haloamidal that subsequently undergoes a palladium insertion.

Reaction of 4-ethoxycarbonyl-2-phenyl-4,5-dihydrooxazol-5-one with organolead(IV) triacetates. A route to some α-arylglycine and α-vinylglycine derivatives

4-Ethoxycarbonyl-2-phenyl-4,5-dihydrooxazol-5-one undergoes rapid arylation and vinylation with arylead triacetates and (E)-styryllead triacetates, respectively. The resulting moisture-sensitive 4-aryl- and 4-styryl-oxazolones undergo hydrolysis and decar

Arylation of 4-Ethoxycarbonyl-2-phenyloxazol-5-one by Aryllead Triacetates: A Convenient Route to α-Arylglycines

4-Ethoxycarbonyl-2-phenyloxazol-5-one, which exists in chloroform as the enol 2, undergoes rapid arylation under very mild conditions with aryllead(IV) triacetates to give almost quantitative yields of 4-aryl-4-ethoxycarbonyl-2-phenyloxazol-5-ones 3, whic