869470-48-4

Upstream product

• 77648-21-6 ethyl 2-amino-2-(4-methoxyphenyl) acetate 
• 98-88-4 benzoyl chloride 
• 924-44-7 glyoxylic acid ethyl ester 
• 55-21-0 benzamide 
• 100-66-3 methoxybenzene 
• 77629-84-6 (±)-ethyl 2-azido-2-(4-methoxyphenyl)acetate 
• 77629-83-5 ethyl 2-bromo-2-(4-methoxyphenyl) acetate 
• 14062-18-1 ethyl p-methoxyphenylacetate 

Downstream Products

• 136603-01-5 2-phenyl-4-(p-methoxyphenyl)-4H-oxazolin-5-one 
• 56674-30-7 2-(benzamido)-2-(4-methoxyphenyl) acetic acid 

Relevant academic research and scientific papers

Iron-catalyzed three-component synthesis of α-amino acid derivatives

An efficient, iron-catalyzed, three-component synthesis of arylglycines starting from readily available amides, glyoxalates, and arenes or heteroarenes has been developed. This method provides a versatile, atom-economic, and cost-effective route to arylglycines with water as the only byproduct. With carbamates as the amide component, various synthetically useful N-protected arylglycine derivatives could be prepared. An iron-catalyzed three-component reaction between amides or carbamates, glyoxylic acid derivatives, and (hetero)aromatics has been developed. This method provides a versatile, atom-economic, and cost-effective route to arylglycines with water as the only byproduct.

Bismuth- and Iron-Catalyzed Three-Component Synthesis of α-Amino Acid Derivatives: A Simple and Convenient Route to α-Arylglycines

Efficient bismuth- and iron-catalyzed three-component syntheses of α-arylglycines have been developed. These methods provide a general, atom-economic route to various N-protected α-arylglycines starting from readily available amides (or carbamates), glyoxalates, and (hetero)arenes with water as the only by-product. Scope and limitations of bismuth- and iron-catalyzed reactions are discussed and compared. In addition, mechanistic investigations as well as initial forays into stereoselective three-component reactions are presented.

Bi(OTf)3-catalyzed three-component synthesis of α-amino acid derivatives

A highly efficient Bi(OTf)3-catalyzed multicomponent synthesis of arylglycines from readily available starting materials is described. The reaction proceeds under mild conditions and provides a general route to various N-protected arylglycines. the Partner Organisations 2014.

Diastereochemical diversity of imidazoline scaffolds via substrate controlled TMSCI mediated cycloaddition of azlactones

(Chemical Equation Presented) We report herein a trimethylsilyl chloride mediated substrate controlled 1,3-dipolar cycloaddition for the diastereoselective synthesis of either syn- or anti-imidazolines. This method provides scaffolds with four points of diversity and control over two stereocenters.